Evidence map›Paper›PMID 40650018›Full record

ArticleInternational journal of molecular sciences2025

Molecular Study from the Signaling Pathways of Four Potential

Lucía Cremades-Jimeno, María López-Ramos, Rubén Fernández-Santamaría, María Ángeles De Pedro, Ignacio Mahillo, Cristina Rosales-Ariza, José María Olaguibel, Victoria Del Pozo, María Luisa Caballero, Juan Alberto Luna-Porta and 7 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Lucía Cremades-JimenoImmunology Department, IIS-Fundación Jiménez Díaz-UAM, 28040 Madrid, Spain.ORCID 0000-0002-8094-5295
María López-RamosImmunology Department, IIS-Fundación Jiménez Díaz-UAM, 28040 Madrid, Spain.
Rubén Fernández-SantamaríaImmunology Department, IIS-Fundación Jiménez Díaz-UAM, 28040 Madrid, Spain.ORCID 0000-0002-0255-4280
María Ángeles De PedroImmunology Department, IIS-Fundación Jiménez Díaz-UAM, 28040 Madrid, Spain.ORCID 0000-0002-8989-2468
Ignacio MahilloBiostatistics and Epidemiology Unit, University Hospital Fundación Jiménez Díaz, 28040 Madrid, Spain.ORCID 0000-0003-0558-6541
Cristina Rosales-ArizaImmunology Department, IIS-Fundación Jiménez Díaz-UAM, 28040 Madrid, Spain.
José María OlaguibelAllergology Service, University Hospital of Navarra, 31008 Pamplona, Spain.
Victoria Del PozoImmunology Department, IIS-Fundación Jiménez Díaz-UAM, 28040 Madrid, Spain.ORCID 0000-0001-6228-1969
María Luisa CaballeroCiber de Enfermedades Respiratorias (CIBERES), 28029 Madrid, Spain.ORCID 0000-0002-9207-6445
Juan Alberto Luna-PortaCiber de Enfermedades Respiratorias (CIBERES), 28029 Madrid, Spain.ORCID 0000-0003-0280-0143
Santiago QuirceCiber de Enfermedades Respiratorias (CIBERES), 28029 Madrid, Spain.ORCID 0000-0001-8086-0921
Blanca BarrosoAllergy Department, University Hospital Fundación Jiménez Díaz, 28040 Madrid, Spain.
Diana BetancorAllergy Department, University Hospital Fundación Jiménez Díaz, 28040 Madrid, Spain.
Marcela Valverde-MongeAllergy Department, University Hospital Fundación Jiménez Díaz, 28040 Madrid, Spain.
Joaquín SastreCiber de Enfermedades Respiratorias (CIBERES), 28029 Madrid, Spain.
Selene BaosImmunology Department, IIS-Fundación Jiménez Díaz-UAM, 28040 Madrid, Spain.ORCID 0000-0002-6398-417X
Blanca CárdabaImmunology Department, IIS-Fundación Jiménez Díaz-UAM, 28040 Madrid, Spain.ORCID 0000-0003-0142-9901

Funding

This research was funded in part by research grant PI20/00903 and PI23/00524 cofunded by FEDER, CIBERES (ISCIII, 0013), RETIC (RD09/0076/00101) from the Fondo de Investigación Sanitaria (Ministerio de Ciencia, Innovación y Univerdidades, Spain) and in par PI20/00903 and PI23/00524, CD23/00118, FI24/00194, PEJD-2019-PRE/BMD-16537, PEJ-2017-AI/SAL-5938.
6 · The paper itself

Abstract

Asthma is a chronic and heterogeneous inflammatory airway disease with diverse clinical endotypes and limited curative treatment options. Recent systems biology analyses identified four potential molecular

Indexed as

AsthmaProto-Oncogene Proteins c-aktSignal TransductionSTAT1 Transcription FactorToll-Like Receptor 4AdultBiomarkersCase-Control StudiesFemaleHumansLeukocytes, MononuclearMaleMiddle AgedAKT1 protein, humanBiomarkersProto-Oncogene Proteins c-aktSTAT1 protein, humanSTAT1 Transcription FactorTLR4 protein, humanToll-Like Receptor 4AKT1allergic asthma (AA)asthmabiomarkersgene expressionMAPK13nonallergic asthma (NA)peripheral blood mononuclear cells (PBMCs)signaling pathwaysSTAT1TLR4

Identifiers

PMID40650018
PMCPMC12249927

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.