Evidence map›Paper›PMID 40649996›Full record

ArticleInternational journal of molecular sciences2025

Host-Virus Interface in Persistent SARS-CoV-2 Infections: Viral Characteristic Evolution and Gene Expression Profiling Analysis.

Athok Shofiudin Maarif, Yukari Nishikawa, Miyako Takata, Kyosuke Kanai, Edo Riyandani, Kengo Mukuda, Momone Mimura, Kosuke Yamaguchi, Hiroyuki Kato, Ryo Okamoto and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Athok Shofiudin MaarifDivision of Infectious Diseases, Graduate School of Medicine, Faculty of Medicine, Tottori University, Nishi-cho 86, Yonago 683-8503, Tottori, Japan.
Yukari NishikawaDivision of Infectious Diseases, Graduate School of Medicine, Faculty of Medicine, Tottori University, Nishi-cho 86, Yonago 683-8503, Tottori, Japan.
Miyako TakataDivision of School of Health Science, Department of Pathobiological Science and Technology, Faculty of Medicine, Tottori University, Yonago Nishi-cho 86, Yonago 683-8503, Tottori, Japan.
Kyosuke KanaiDivision of Virology, Department of Microbiology and Immunology, Faculty of Medicine, Tottori University, Nishi-cho 86, Yonago 683-8503, Tottori, Japan.ORCID 0000-0002-7984-207X
Edo RiyandaniDivision of Infectious Diseases, Graduate School of Medicine, Faculty of Medicine, Tottori University, Nishi-cho 86, Yonago 683-8503, Tottori, Japan.
Kengo MukudaDivision of Infectious Diseases, Graduate School of Medicine, Faculty of Medicine, Tottori University, Nishi-cho 86, Yonago 683-8503, Tottori, Japan.
Momone MimuraDivision of School of Health Science, Department of Pathobiological Science and Technology, Faculty of Medicine, Tottori University, Yonago Nishi-cho 86, Yonago 683-8503, Tottori, Japan.
Kosuke YamaguchiDepartment of Multidisciplinary Internal Medicine, Division of Respiratory Medicine and Rheumatology, Faculty of Medicine, Tottori University, Nishi-cho 86, Yonago 683-8503, Tottori, Japan.ORCID 0009-0000-8866-0326
Hiroyuki KatoDivision of Infectious Diseases, Graduate School of Medicine, Faculty of Medicine, Tottori University, Nishi-cho 86, Yonago 683-8503, Tottori, Japan.
Ryo OkamotoDivision of Infectious Diseases, Graduate School of Medicine, Faculty of Medicine, Tottori University, Nishi-cho 86, Yonago 683-8503, Tottori, Japan.
Kensaku OkadaDivision of Infectious Diseases, Graduate School of Medicine, Faculty of Medicine, Tottori University, Nishi-cho 86, Yonago 683-8503, Tottori, Japan.
Tsuyoshi KitauraDivision of Infectious Diseases, Graduate School of Medicine, Faculty of Medicine, Tottori University, Nishi-cho 86, Yonago 683-8503, Tottori, Japan.
Masaki NakamotoDivision of Infectious Diseases, Graduate School of Medicine, Faculty of Medicine, Tottori University, Nishi-cho 86, Yonago 683-8503, Tottori, Japan.
Akira YamasakiDepartment of Multidisciplinary Internal Medicine, Division of Respiratory Medicine and Rheumatology, Faculty of Medicine, Tottori University, Nishi-cho 86, Yonago 683-8503, Tottori, Japan.ORCID 0000-0001-5175-2729
Seiji KageyamaDivision of Virology, Department of Microbiology and Immunology, Faculty of Medicine, Tottori University, Nishi-cho 86, Yonago 683-8503, Tottori, Japan.ORCID 0000-0002-5220-6137
Hiroki ChikumiDivision of Infectious Diseases, Graduate School of Medicine, Faculty of Medicine, Tottori University, Nishi-cho 86, Yonago 683-8503, Tottori, Japan.

Funding

Japan Society for the Promotion of Science 25K11454
6 · The paper itself

Abstract

Persistent SARS-CoV-2 infections involve prolonged viral replication and immune system interactions, potentially driving viral evolution and immune escape. This study examines viral characteristics and host gene expression changes in persistent infections. The nasopharyngeal samples from four patients with persistent SARS-CoV-2 infections at Tottori University Hospital, Japan, were analyzed. Viral isolates were cultured, and infectivity was assessed using TCID

Indexed as

COVID-19Host-Pathogen InteractionsSARS-CoV-2Evolution, MolecularGene Expression ProfilingGenome, ViralHumansMaleMiddle AgedMutationSpike Glycoprotein, CoronavirusSpike Glycoprotein, Coronavirusgene expressionGO enrichmenthost–virus interactionimmune responsepersistent infectionSARS-CoV-2viral evolution

Identifiers

PMID40649996
PMCPMC12249595

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.