ReviewInternational journal of molecular sciences2025
The Morphogenesis, Pathogenesis, and Molecular Regulation of Human Tooth Development-A Histological Review.
Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Tooth agenesis affects one in four individuals in a multicenter saudi sample: a cross-sectional study of hypodontia and regional variation.BMC oral health · 2026Article
- Mechanical control in dental and jaw morphogenesis and remodeling.International journal of oral science · 2026Review
- Stem Cell-based Therapeutic and Endogenous Regeneration Approaches for Congenital Tooth Agenesis.Stem cell reviews and reports · 2026Review
- Craniofacial size in individuals with supernumerary teeth: A multicenter geometric morphometric study.BMC oral health · 2026Article
- Stem cell-driven biomedical technologies for tooth regeneration: engineering scaffolds, organoid models, and molecular targeted strategies.Stem cell research & therapy · 2026Review
- ECM-Syndecan-4-FAK signaling is associated with epithelial invagination and buccolingual asymmetry during mandibular molar development.Frontiers in physiology · 2026Article
- TRPV1 mediates mitochondrial dysfunction in hyperthermia-induced ameloblast mineralization defects.Frontiers in cell and developmental biology · 2026Article
- Metabolic programming in tooth development: a regulatory network from energy substrates to signaling instructions.Frontiers in cell and developmental biology · 2026Review
- Article
- Review
- Urinary fluoride and dental fluorosis in relation to kidney and liver function in adolescents and young adults in the United States.Environmental health : a global access science source · 2025Article
- Relationship of finger dermatoglyphics with ameloglyphics and their values as dental caries predictors in primary teeth.BMC oral health · 2025Article
- Mandibular extracellular vesicles mediate morphogenesis and mineralization of tooth germs in miniature swine through the miR-206/HDAC4 signaling axis.Frontiers in cell and developmental biology · 2025Article
- Vascular remodeling and microvessel density in inflammatory radicular cysts: a CD34 immunohistochemical analysis.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Odontogenesis, the development of teeth, is a complex, multistage process that unfolds from early embryogenesis through tooth eruption and maturation. It serves as a classical model of organogenesis due to the intricate reciprocal interactions between cranial neural crest-derived mesenchyme and oral epithelium. This narrative review synthesizes current scientific knowledge on human tooth development, tracing the journey from the embryological origins in the first branchial arch to the formation of a fully functional tooth and its supporting structures. Key morphogenetic stages-bud, cap, bell, apposition, and root formation-are described in detail, highlighting the cellular events and histological features characterizing each stage. We discuss the molecular and cellular regulatory networks that orchestrate odontogenesis, including the conserved signaling pathways (Wnt, BMP, FGF, SHH, EDA) and transcription factors (e.g., PAX9, MSX1/2, PITX2) that drive tissue patterning and cell differentiation. The coordinated development of supporting periodontal tissues (cementum, periodontal ligament, alveolar bone, gingiva) is also examined as an integral part of tooth organogenesis. Finally, developmental anomalies (such as variations in tooth number, size, and form) and the fate of residual embryonic epithelial cells are reviewed to underscore the clinical significance of developmental processes. Understanding the normal course of odontogenesis provides crucial insight into congenital dental disorders and lays a foundation for advances in regenerative dental medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.