Evidence map›Paper›PMID 40649985›Full record

ArticleInternational journal of molecular sciences2025

Investigating Endogenous Opioids Unravels the Mechanisms Behind Opioid-Induced Constipation, a Mathematical Modeling Approach.

Celvic Coomber, Surahit Chewle, Christopher Secker, Konstantin Fackeldey, Marcus Weber, Stefanie Winkelmann, Christof Schütte, Vikram Sunkara

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Celvic CoomberInstitute of Mathematics, Technische Universität Berlin, 10623 Berlin, Germany.
Surahit ChewleZuse Institute Berlin, 14195 Berlin, Germany.ORCID 0000-0002-1428-349X
Christopher SeckerZuse Institute Berlin, 14195 Berlin, Germany.ORCID 0000-0002-7222-536X
Konstantin FackeldeyInstitute of Mathematics, Technische Universität Berlin, 10623 Berlin, Germany.
Marcus WeberZuse Institute Berlin, 14195 Berlin, Germany.
Stefanie WinkelmannZuse Institute Berlin, 14195 Berlin, Germany.ORCID 0000-0002-0114-7819
Christof SchütteZuse Institute Berlin, 14195 Berlin, Germany.ORCID 0000-0001-5232-2683
Vikram SunkaraZuse Institute Berlin, 14195 Berlin, Germany.ORCID 0000-0002-4940-8344

Funding

Deutsche Forschungsgemeinschaft 235221301Federal Ministry of Education and Research 01GQ2109BThe Berlin Mathematics Research Center MATH+ EXC-2046/1 project ID: 390685689
6 · The paper itself

Abstract

Endogenous opioids, such as Endomorphin-2, are not typically associated with severe constipation, unlike pharmaceutical opioids, which induce opioid-induced constipation (OIC) by activating

Indexed as

Analgesics, OpioidConstipationModels, TheoreticalOpioid-Induced ConstipationAdenylyl CyclasesAnimalsCyclic AMPEnteric Nervous SystemFentanylHumansModels, BiologicalMorphineOligopeptidesReceptors, Opioid, muSerotoninSignal TransductionAdenylyl CyclasesAnalgesics, OpioidCyclic AMPendomorphin 2FentanylMorphineOligopeptidesReceptors, Opioid, muSerotoninEndomorphin-2enteric nervous system (ENS)mathematical modelingopioid-induced constipation (OIC)

Identifiers

PMID40649985
PMCPMC12250360

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.