Evidence map›Paper›PMID 40649943›Full record

ArticleInternational journal of molecular sciences2025

Transcriptomic Profiling of Lesional and Perilesional Skin in Atopic Dermatitis Suggests Barrier Dysfunction, Inflammatory Activation, and Alterations to Vitamin D Metabolism.

Teresa Grieco, Giovanni Paolino, Elisa Moliterni, Camilla Chello, Alvise Sernicola, Colin Gerard Egan, Mariangela Morelli, Fabrizio Nannipieri, Santina Battaglia, Marina Accoto and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Teresa GriecoDermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-7855-6621
Giovanni PaolinoUnit of Dermatology and Cosmetology, IRCCS Ospedale San Raffaele, 20132 Milan, Italy.
Elisa MoliterniDermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.
Camilla ChelloDermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.
Alvise SernicolaDermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-1985-0326
Colin Gerard EganCE Medical Writing SRLS, 56021 Pisa, Italy.ORCID 0000-0002-6942-7147
Mariangela MorelliFondazione Pisana per la Scienza, 56017 Pisa, Italy.
Fabrizio NannipieriClinical Research, Abiogen Pharma, 56121 Pisa, Italy.
Santina BattagliaClinical Research, Abiogen Pharma, 56121 Pisa, Italy.ORCID 0009-0005-9591-1046
Marina AccotoClinical Research, Abiogen Pharma, 56121 Pisa, Italy.
Erika TirottaClinical Research, Abiogen Pharma, 56121 Pisa, Italy.
Silvia TrasciattiGalileo Research Srl, 56019 Pisa, Italy.
Silvano BonarettiGalileo Research Srl, 56019 Pisa, Italy.
Giovanni PellacaniDermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.
Stefano CalvieriDermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.

Funding

Abiogen Pharma S.p.A N7A
6 · The paper itself

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease marked by impaired barrier function and immune dysregulation. This study explores transcriptomic differences between lesional (IL) and perilesional (PL) skin in patients with AD, focusing on barrier-related and vitamin D-associated pathways. RNA sequencing was performed on matched IL and PL biopsies from 21 adults with moderate-to-severe AD. Differential gene expression, pathway enrichment, and correlation analysis with clinical variables were assessed. A total of 8817 genes were differentially expressed in IL versus PL skin (padj < 0.05). Among genes with the highest level of dysregulation, strong upregulation was observed for inflammatory mediators (

Indexed as

Dermatitis, AtopicGene Expression ProfilingSkinTranscriptomeVitamin D25-Hydroxyvitamin D3 1-alpha-HydroxylaseAdultConnexin 26FemaleFilaggrin ProteinsHumansInflammationMaleMiddle AgedVitamin D3 24-Hydroxylase25-Hydroxyvitamin D3 1-alpha-HydroxylaseConnexin 26CYP24A1 protein, humanCYP27B1 protein, humanFilaggrin ProteinsFLG2 protein, humanFLG protein, humanGJB2 protein, humanVitamin DVitamin D3 24-Hydroxylaseatopic dermatitisgene expressionskin barrier maintenancevitamin D receptor

Identifiers

PMID40649943
PMCPMC12249519

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.