Evidence map›Paper›PMID 40649930›Full record

ArticleInternational journal of molecular sciences2025

Associations Between Gut Microbiota Composition and Impulse Control Disorders in Parkinson's Disease.

Sheng-Hsuan Lin, Ru-Jen Lin, Chia-Ling Chu, Yan-Lin Chen, Shih-Chen Fu

Abstract read
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Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sheng-Hsuan LinInstitute of Statistics, National Yang Ming Chiao Tung University, Hsinchu 300093, Taiwan.
Ru-Jen LinDepartment of Neurology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu 300195, Taiwan.
Chia-Ling ChuInstitute of Statistics, National Yang Ming Chiao Tung University, Hsinchu 300093, Taiwan.
Yan-Lin ChenInstitute of Statistics, National Yang Ming Chiao Tung University, Hsinchu 300093, Taiwan.
Shih-Chen FuDepartment of Biochemistry and Molecular Medicine, National Dong Hwa University, Hualien 97401, Taiwan.ORCID 0000-0001-9591-8698

Funding

National Science and Technology Council MOST 111-2628-M-A49-004-MY3National Science and Technology Council NSTC 113-2314-B-259 -001 -MY3
6 · The paper itself

Abstract

Impulse control disorders (ICDs) are a debilitating non-motor symptom of Parkinson's disease (PD), often associated with dopaminergic therapy. However, their occurrence in some patients but not others suggests additional biological mechanisms, including the gut microbiome. In this study, we analyzed 191 PD patients (14 with ICDs, 177 without) using 16S rRNA gene sequencing to explore the association between gut microbiota and ICDs. No significant differences were observed in alpha or beta diversity between groups, but several bacterial taxa showed differential abundances. Notably,

Indexed as

Disruptive, Impulse Control, and Conduct DisordersGastrointestinal MicrobiomeParkinson DiseaseAgedBacteriaFemaleHumansMaleMiddle AgedRNA, Ribosomal, 16SRNA, Ribosomal, 16Sgut–brain axisgut microbiotaimpulse control disordersmicrobiome metabolismParkinson’s disease

Identifiers

PMID40649930
PMCPMC12249796

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.