Evidence map›Paper›PMID 40649927›Full record

ArticleInternational journal of molecular sciences2025

Potential Molecular Biomarkers of Preeclampsia-A Pilot Study.

Anna Romała, Eliza Matuszewska-Mach, Wiesław Markwitz, Maciej Brązert, Paulina Borysewicz, Dagmara Pietkiewicz, Jan Matysiak, Krzysztof Drews, Agata Szpera

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Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anna RomałaDepartment of Perinatology, Poznan University of Medical Sciences, Polna 33 Street, 60-535 Poznan, Poland.ORCID 0000-0003-1747-2656
Eliza Matuszewska-MachDepartment of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Rokietnicka 3 Street, 60-806 Poznan, Poland.ORCID 0000-0002-5765-2603
Wiesław MarkwitzDepartment of Perinatology, Poznan University of Medical Sciences, Polna 33 Street, 60-535 Poznan, Poland.
Maciej BrązertDepartment of Diagnostics and Treatment of Fertility, Poznan University of Medical Sciences, Polna 33 Street, 60-535 Poznan, Poland.ORCID 0000-0002-2423-8238
Paulina BorysewiczThe Students Scientific Society, Poznan University of Medical Sciences, Rokietnicka 5 Street, 60-806 Poznan, Poland.
Dagmara PietkiewiczDepartment of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Rokietnicka 3 Street, 60-806 Poznan, Poland.ORCID 0000-0001-8163-6825
Jan MatysiakDepartment of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Rokietnicka 3 Street, 60-806 Poznan, Poland.ORCID 0000-0002-9993-1504
Krzysztof DrewsFaculty of Medicine, Poznan Medical University, Bułgarska 55 Street, 60-320 Poznan, Poland.
Agata SzperaDepartment of Perinatology, Poznan University of Medical Sciences, Polna 33 Street, 60-535 Poznan, Poland.ORCID 0000-0002-5546-4799

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preeclampsia, one of the leading causes of maternal and fetal morbidity and mortality, affects approximately 3-5% of pregnancies worldwide. However, its etiology remains poorly understood. The aim of this study was to identify molecular markers of preeclampsia. Protein concentrations in blood and urine were determined using the Bio-Plex Kidney Toxicity 1 assay Bio-Rad, Hercules, CA, USA followed by magnetic separation and flow cytometry. This study included 51 patients with preeclampsia and 25 healthy pregnant women. The results revealed that five out of the six serum biomarkers of kidney injury were elevated in the preeclampsia group compared to the control group (calbindin 1, clusterin, glutathione transferase pi (GSTP1), monocyte chemotactic protein 1 (MCP-1), and kidney injury molecule type 1 (KIM-1)). Additionally, the serum concentrations of calbindin 1, clusterin, GSTP1, and KIM-1 were significantly higher in both early-onset and late-onset preeclampsia compared to the control group. The analysis of urinary proteins showed that only the KIM-1 concentration was elevated in late-onset preeclampsia compared to the control group. These findings suggest that the calbindin 1, clusterin, GSTP1, KIM-1, and MCP-1 concentrations in maternal plasma could serve as potential biomarkers for monitoring kidney injury in preeclamptic women. This study provides a foundation for future research to explore novel biomarkers of preeclampsia and renal injury in pregnant women.

Indexed as

BiomarkersPre-EclampsiaAdultCase-Control StudiesChemokine CCL2ClusterinFemaleGlutathione S-Transferase piHepatitis A Virus Cellular Receptor 1HumansPilot ProjectsPregnancyBiomarkersCCL2 protein, humanChemokine CCL2CLU protein, humanClusterinGlutathione S-Transferase piGSTP1 protein, humanHAVCR1 protein, humanHepatitis A Virus Cellular Receptor 1biomarkerscalbindin 1clusterinGSTP1IL-18KIM-1MCP-1preeclampsia

Identifiers

PMID40649927
PMCPMC12250054

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.