Evidence map›Paper›PMID 40649901›Full record

ArticleInternational journal of molecular sciences2025

Ruxolitinib Modulates P-Glycoprotein Function, Delays T Cell Activation, and Impairs CCL19 Chemokine-Directed Migration in Human Cytotoxic T Lymphocytes.

Kipchumba Biwott, Algirmaa Lkhamkhuu, Nimrah Ghaffar, Albert Bálint Papp, Nastaran Tarban, Katalin Goda, Zsolt Bacso

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kipchumba BiwottDepartment of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.ORCID 0000-0002-7501-5835
Algirmaa LkhamkhuuDepartment of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.ORCID 0000-0003-1581-179X
Nimrah GhaffarDepartment of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Albert Bálint PappDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Nastaran TarbanDoctoral School of Molecular Cell and Immune Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Katalin GodaDepartment of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.ORCID 0000-0003-2001-7400
Zsolt BacsoDepartment of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.ORCID 0000-0001-6885-3796

Funding

Hungarian Government Stipendium Hungaricum scholarship supported the work of A.L.Hungarian Government Stipendium Hungaricum scholarship supported the work of K.B.University of Debrecen DETKA-2024 Scientific Research Bridging FundUniversity of Debrecen OTKA Bridging Research FundUniversity of Debrecen Publication Science Support ProgramUniversity of Debrecen Science Financing Support
6 · The paper itself

Abstract

Ruxolitinib, a clinically approved JAK1/2 inhibitor used in the treatment of hematologic malignancies and inflammatory conditions, has been shown to interfere with the function of cytotoxic T lymphocytes (CTLs). Previous studies supported the involvement of the multidrug resistance transporter P-glycoprotein (Pgp/ABCB1) in CTL biology; however, the nature of its regulation remains unclear. To address this, we investigated the impact of ruxolitinib on Pgp expression and function in human CD8

Indexed as

ATP Binding Cassette Transporter, Subfamily B, Member 1Cell MovementChemokine CCL19Lymphocyte ActivationPyrazolesT-Lymphocytes, CytotoxicAnimalsCD8-Positive T-LymphocytesHumansMiceNitrilesPyrimidinesATP Binding Cassette Transporter, Subfamily B, Member 1CCL19 protein, humanChemokine CCL19NitrilesPyrazolesPyrimidinesruxolitinibABCB1)CCL19 chemokine-driven migrationCytotoxic T lymphocytes (CTLs)immune modulationJAK-STAT signalingMDR1P-glycoprotein (PgpruxolitinibT cell activation

Identifiers

PMID40649901
PMCPMC12249582

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.