Evidence map›Paper›PMID 40649898›Full record

ArticleInternational journal of molecular sciences2025

Uncovering Anti-Melanoma Mechanisms of

Gen Maxxine C Darilag, Hsuan-Chieh Liu, Cheng-Yang Hsieh, Lemmuel L Tayo, Nicholas Dale D Talubo, Shu-Ching Yang, Ching-Hui Chang, Ying-Pin Huang, Shih-Chi Lee, Yung-Chuan Liu and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Gen Maxxine C DarilagSchool of Chemical, Biological, and Materials Engineering and Sciences, Mapúa University, Metro Manila 1002, Philippines.ORCID 0009-0003-7023-104X
Hsuan-Chieh LiuDepartment of Chemical Engineering, National Chung Hsing University, Taichung 402, Taiwan.ORCID 0009-0006-6142-5450
Cheng-Yang HsiehDepartment of Chemical and Materials Engineering, National I-Lan University, I-Lan 260, Taiwan.ORCID 0000-0003-4225-9128
Lemmuel L TayoDepartment of Biology, School of Health Sciences, Mapúa University, Makati 1200, Philippines.
Nicholas Dale D TaluboSchool of Chemical, Biological, and Materials Engineering and Sciences, Mapúa University, Metro Manila 1002, Philippines.ORCID 0009-0008-6658-0091
Shu-Ching YangBiomass Materials Technology Department, Agri-Industrial Systems Technology Division, Central Region Campus, Industrial Technology Research Institute, Nantou 540, Taiwan.
Ching-Hui ChangBiomass Materials Technology Department, Agri-Industrial Systems Technology Division, Central Region Campus, Industrial Technology Research Institute, Nantou 540, Taiwan.
Ying-Pin HuangBiomass Materials Technology Department, Agri-Industrial Systems Technology Division, Central Region Campus, Industrial Technology Research Institute, Nantou 540, Taiwan.
Shih-Chi LeeBiomass Materials Technology Department, Agri-Industrial Systems Technology Division, Central Region Campus, Industrial Technology Research Institute, Nantou 540, Taiwan.ORCID 0000-0001-9407-1691
Yung-Chuan LiuDepartment of Chemical Engineering, National Chung Hsing University, Taichung 402, Taiwan.ORCID 0000-0002-4800-3337
Po-Wei TsaiDepartment of Food Science, National Taiwan Ocean University, Keelung 202, Taiwan.ORCID 0000-0002-1981-5360

Funding

Forestry and Nature Conservation Agency, Ministry of Agriculture, Taiwan FANCA 112AS-7.4.4-FB-e4National Science and Technology Council, Taiwan 2024 International Internship Pilot ProgramNational Science and Technology Council, Taiwan NSTC 112-2221-E-019-074
6 · The paper itself

Abstract

Skin cancer, particularly melanoma, remains a major public health concern due to its high mortality rate. Current treatment options, including chemotherapy with dacarbazine and doxorubicin, have shown limited efficacy, achieving only a 20% objective response rate over six months, along with severe side effects such as cardiotoxicity. Given these limitations, there is a growing interest in herbal medicine as a source of novel anticancer compounds.

Indexed as

Antineoplastic Agents, PhytogenicMelanomaNetwork PharmacologyPlant ExtractsPlant LeavesCyclin-Dependent Kinase 2HumansMolecular Docking SimulationSignal TransductionAntineoplastic Agents, PhytogenicCyclin-Dependent Kinase 2Plant Extractsbamboo leavesnaringinpathway analysisskin cancer

Identifiers

PMID40649898
PMCPMC12250477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.