Evidence map›Paper›PMID 40649871›Full record

Trial reportInternational journal of molecular sciences2025

LC-MS/MS-Based Determination of Ambroxol in Human Plasma and Cerebrospinal Fluid: Validation and Applicability in a Phase II Study on GBA-Associated Parkinson's Disease Patients.

Valentina Franco, Michela Palmisani, Fabiana Colucci, Rosa De Micco, Simone Aloisio, Federico Cazzaniga, Silvia Cerri, Francesca Crema, Francesca Dattrino, Barbara Garavaglia and 11 more

Abstract readClinical Trial, Phase IIMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Valentina FrancoClinical and Experimental Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, 27100 Pavia, Italy.
Michela PalmisaniClinical and Experimental Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, 27100 Pavia, Italy.ORCID 0009-0005-7155-9447
Fabiana ColucciParkinson and Movement Disorders Unit, Department of Clinical Neurosciences, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milano, Italy.ORCID 0000-0003-1945-8153
Rosa De MiccoDepartment of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Simone AloisioDepartment of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0009-0006-4675-6059
Federico CazzanigaLaboratory of Clinical Pathology, Unit of Laboratory Medicine, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milano, Italy.
Silvia CerriIRCCS Mondino Foundation, 27100 Pavia, Italy.ORCID 0000-0002-6466-5381
Francesca CremaClinical and Experimental Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, 27100 Pavia, Italy.
Francesca DattrinoClinical and Experimental Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, 27100 Pavia, Italy.ORCID 0009-0000-3794-1363
Barbara GaravagliaUnit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milano, Italy.ORCID 0000-0003-4323-9145
Matteo GastaldiIRCCS Mondino Foundation, 27100 Pavia, Italy.
Pierfrancesco MitrottiIRCCS Mondino Foundation, 27100 Pavia, Italy.ORCID 0000-0003-3574-1290
Fabio ModaLaboratory of Clinical Pathology, Unit of Laboratory Medicine, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milano, Italy.ORCID 0000-0002-2820-9880
Paola RotaDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, 20133 Milan, Italy.ORCID 0000-0001-5795-4989
Rita StiusoIRCCS Mondino Foundation, 27100 Pavia, Italy.ORCID 0009-0007-5595-9066
Cristina TassorelliIRCCS Mondino Foundation, 27100 Pavia, Italy.ORCID 0000-0003-1513-2113
Roberto EleopraParkinson and Movement Disorders Unit, Department of Clinical Neurosciences, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milano, Italy.ORCID 0000-0002-6035-9715
Alessandro TessitoreDepartment of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Enza Maria ValenteIRCCS Mondino Foundation, 27100 Pavia, Italy.ORCID 0000-0002-0600-6820
Micol AvenaliIRCCS Mondino Foundation, 27100 Pavia, Italy.ORCID 0000-0002-7880-9921
Roberto CiliaParkinson and Movement Disorders Unit, Department of Clinical Neurosciences, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milano, Italy.

Funding

Italian Ministry of Health GR-2018-12366771
6 · The paper itself

Abstract

Heterozygous mutations in the

Indexed as

AmbroxolGlucosylceramidaseParkinson DiseaseTandem Mass SpectrometryAgedChromatography, LiquidFemaleHumansLiquid Chromatography-Mass SpectrometryMaleMiddle AgedSolid Phase ExtractionAmbroxolGBA protein, humanGlucosylceramidaseambroxolcerebrospinal fluidglucocerebrosidaseLC-MS/MSParkinson’s Diseaseplasma

Identifiers

PMID40649871
PMCPMC12249730

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.