Quinazoline Derivative kzl052 Suppresses Prostate Cancer by Targeting WRN Helicase to Stabilize DNA Replication Forks.

Jia Yu, Gang Yu, Sha Cheng, Liangliang Hu, Ningning Zan, Bixue Xu, Ying Cao, Heng Luo

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Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Jia YuMedical College, Guizhou University, Guiyang 550025, China.ORCID 0009-0000-4870-8540

Gang YuState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Guizhou Medical University, Guiyang 550014, China.

Sha ChengState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Guizhou Medical University, Guiyang 550014, China.

Liangliang HuState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Guizhou Medical University, Guiyang 550014, China.

Ningning ZanState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Guizhou Medical University, Guiyang 550014, China.

Bixue XuState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Guizhou Medical University, Guiyang 550014, China.

Ying CaoMedical College, Guizhou University, Guiyang 550025, China.

Heng LuoState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Guizhou Medical University, Guiyang 550014, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

WRN helicases play a key role in DNA replication, repair, and other processes in a variety of tumors. It has become one of the hot targets of genotoxic drugs, but the effect and mechanism of targeting WRN against prostate cancer is still unclear. In our previous study, we found a quinazoline compound kzl052, which has a WRN-dependent inhibitory effect on prostate cancer cells, but its molecular mechanism needs to be further explored. In this study, kzl052 significantly inhibited the growth of PC3 (IC

Indexed as

Antineoplastic AgentsDNA ReplicationProstatic NeoplasmsQuinazolinesWerner Syndrome HelicaseAnimalsCell Line, TumorCell ProliferationHumansMaleMiceXenograft Model Antitumor AssaysAntineoplastic AgentsQuinazolinesWerner Syndrome HelicaseWRN protein, humanDNA replication forkprostate cancerquinazoline derivativeWRN helicase

Identifiers

PMID40649870

DOI10.3390/ijms26136093

PMCPMC12249509

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.