Evidence map›Paper›PMID 40649812›Full record

ArticleInternational journal of molecular sciences2025

Synthesis of Novel Podophyllotoxin-Benzothiazole Congeners and Their Biological Evaluation as Anticancer Agents.

Pramukti Nawar Rai'dah, Zuzanna Molęda, Aleksandra Osińska, Armand Budzianowski, Izabela Młynarczuk-Biały, Zbigniew Czarnocki

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pramukti Nawar Rai'dahFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.ORCID 0000-0002-0588-8841
Zuzanna MolędaFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.ORCID 0000-0002-0868-2216
Aleksandra OsińskaFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.
Armand BudzianowskiNational Centre for Nuclear Research, A. Sołtana 7, 05-400 Otwock, Poland.ORCID 0000-0002-6536-7108
Izabela Młynarczuk-BiałyDepartment of Histology and Embryology, Medical University of Warsaw, Chałubińskiego 5, 02-004 Warsaw, Poland.ORCID 0000-0002-5192-6415
Zbigniew CzarnockiFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.ORCID 0000-0002-6581-9282

Funding

University of Warsaw BOB-661-1622/2024
6 · The paper itself

Abstract

A series of novel podophyllotoxin derivatives containing benzothiazole scaffolds were synthesized and evaluated for their in vitro cytotoxic activity against five cancer cell lines (MCF-7, SKOV-3, B16F10, LOVO, and HeLa). Two compounds,

Indexed as

Antineoplastic AgentsBenzothiazolesPodophyllotoxinCell Line, TumorCell ProliferationHeLa CellsHumansMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipTubulinAntineoplastic AgentsbenzothiazoleBenzothiazolesPodophyllotoxinTubulinanticancerbenzothiazolecytotoxicitypodophyllotoxintubulin

Identifiers

PMID40649812
PMCPMC12250170

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.