Evidence map›Paper›PMID 40649779›Full record

SynthesisInternational journal of molecular sciences2025

Common SNCA Genetic Variants and Parkinson's Disease Risk: A Systematic Review and Meta-Analysis.

Raziyeh Mohammadi, Mahdi Shirazi, Sayedeh Fatemeh Sadat-Madani, Matthew Zachary Yeo Cheng Long, Corrine Lee Singh, Jayne Y Tan, Xiao Deng, Seyed Majid Hashemi Fard, Samuel Y E Ng, Adeline S L Ng and 2 more

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Raziyeh MohammadiDuke-NUS Medical School, National University of Singapore, Singapore 169857, Singapore.ORCID 0000-0002-5226-1734
Mahdi ShiraziDepartment of Physics, Isfahan University of Technology, Isfahan 84156-83111, Iran.
Sayedeh Fatemeh Sadat-MadaniSchool of Medicine, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
Matthew Zachary Yeo Cheng LongMinistry of Health Holdings (MOHH), Singapore 139691, Singapore.
Corrine Lee SinghYong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.ORCID 0009-0007-2945-5745
Jayne Y TanDepartment of Neurology, National Neuroscience Institute, Singapore 308433, Singapore.
Xiao DengDepartment of Neurology, National Neuroscience Institute, Singapore 308433, Singapore.
Seyed Majid Hashemi FardDuke-NUS Medical School, National University of Singapore, Singapore 169857, Singapore.ORCID 0000-0001-5780-4139
Samuel Y E NgDepartment of Research, National Neuroscience Institute, Singapore 308433, Singapore.ORCID 0000-0002-0173-4925
Adeline S L NgDuke-NUS Medical School, National University of Singapore, Singapore 169857, Singapore.
Louis C S TanDuke-NUS Medical School, National University of Singapore, Singapore 169857, Singapore.
Seyed Ehsan SaffariDuke-NUS Medical School, National University of Singapore, Singapore 169857, Singapore.ORCID 0000-0002-6473-4375

Funding

Singapore Ministry of Health's National Medical Research Council MOH-OFLCG18May-0002, MOH-CSAINV21-0005, CNIG22jul-0004
6 · The paper itself

Abstract

The

Indexed as

alpha-SynucleinGenetic Predisposition to DiseaseParkinson DiseasePolymorphism, Single NucleotideAllelesHumansRisk Factorsalpha-SynucleinSNCA protein, humanalpha-synucleinheterogeneityneurodegenerative disorderspersonalized medicine

Identifiers

PMID40649779
PMCPMC12250285

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.