Evidence map›Paper›PMID 40649755›Full record

ArticleInternational journal of molecular sciences2025

Identification and Screening of Novel Antioxidant Peptides from Yak Skin and Their Protective Effect on H

Yan Jin, Nan Zhang, Yurong Huang, Ziyao Zhang, Enhui Jin, Yu Kong, Wenjie Sui, Tao Wu, Min Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yan JinCollege of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin 300457, China.ORCID 0000-0003-3981-7459
Nan ZhangCollege of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin 300457, China.
Yurong HuangCollege of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin 300457, China.
Ziyao ZhangCollege of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin 300457, China.
Enhui JinCollege of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin 300457, China.
Yu KongCollege of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin 300457, China.
Wenjie SuiCollege of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin 300457, China.
Tao WuCollege of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin 300457, China.ORCID 0000-0002-0629-8421
Min ZhangCollege of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin 300457, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To improve the bioavailability of yak by-products, novel antioxidant peptides were prepared and identified from yak skin hydrolysate. The results showed that the ultrafiltration fraction of a molecular weight of less than 1 kDa had the strongest free radical scavenging activity. A total of 219 novel peptides were identified by mass spectrometry and five antioxidant peptides were screened based on molecular docking with Keap1 (LMGPR, GFDGD, FGFDGDF, GHNGLDGL, and GPAGPQGPR). These peptides may bind with Keap1 competitively and exert antioxidant effects by activating the Nrf2/ARE pathway. After synthesis, FGFDGDF showed a better free radical scavenging ability and protective effect on H

Indexed as

AntioxidantsHydrogen PeroxideOxidative StressPeptidesSkinAnimalsCattleHep G2 CellsHumansKelch-Like ECH-Associated Protein 1Molecular Docking SimulationNF-E2-Related Factor 2Oxidation-ReductionAntioxidantsHydrogen PeroxideKEAP1 protein, humanKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2Peptidesantioxidant peptideKeap1-Nrf2/ARE pathwaymolecular dockingoxidative stressyak skin

Identifiers

PMID40649755
PMCPMC12249663

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.