Evidence map›Paper›PMID 40649738›Full record

Observational studyInternational journal of molecular sciences2025

Pain and Sleep Biomarkers in Participants Undergoing Orthopedic Surgeries.

Manish Bhomia, Nicholas A Giordano, Krista B Highland, Keren Lee, Matthew Van Shufflin, Yanru Feng, Alexandra Kane, Raymond B Kroma, Barbara Knollmann-Ritschel

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Manish BhomiaDepartment of Pathology, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD 20814, USA.ORCID 0000-0003-2808-9927
Nicholas A GiordanoNell Hodgson Woodruff School of Nursing, Emory University, 1520 Clifton Road, Atlanta, GA 30322, USA.ORCID 0000-0003-0112-6214
Krista B HighlandDepartment of Anesthesiology, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD 20814, USA.
Keren LeeDepartment of Anesthesiology, Naval Medical Center Portsmouth, 620 John Paul Jones Cir, Portsmouth, VA 23708, USA.
Matthew Van ShufflinDepartment of Anesthesiology, Brooke Army Medical Center, 3551 Roger Brooke Drive, Fort Sam Houston, TX 78234, USA.
Yanru FengDepartment of Pathology, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD 20814, USA.
Alexandra KaneHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.ORCID 0000-0001-9342-1960
Raymond B KromaDrexel University College of Medicine, 60 North 36th Street, Philadelphia, PA 19104, USA.ORCID 0000-0002-2628-916X
Barbara Knollmann-RitschelDepartment of Pathology, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD 20814, USA.

Funding

Uniformed Services University of the Health Sciences HU001-14-2-0041
6 · The paper itself

Abstract

The bidirectional relationship between chronic pain and poor sleep are well reported. Disrupted sleep and chronic pain, either alone or in conjunction, are often associated with poor post-surgical outcomes. However, the relationship between peripheral blood biomarkers and chronic pain and sleep disturbances after orthopedic surgery has not been extensively studied. The goal of this observational prospective study was to conduct an analysis on the relationship of blood cytokines and chemokines with chronic pain and sleep outcomes among US service members undergoing orthopedic surgery. Active-duty service members (N = 114) who underwent orthopedic extremity or spinal surgery were recruited, of whom 69 completed pre-surgery and 64 completed 6-week post-surgery surveys and blood draws. Blood cytokine and chemokine analyses were performed using multiplex immunoassays. Non-parametric correlations with blood cytokine and chemokine showed significant associations with both pre- and post-surgical pain scores whereas no significant correlations were observed with sleep disturbance scores. Increased pain intensity 6 weeks after surgery was positively associated with increased hepatocyte growth factor (ρ

Indexed as

BiomarkersChronic PainOrthopedic ProceduresPostoperative PainSleepSleep Wake DisordersAdultChemokinesCytokinesFemaleHumansMaleMiddle AgedProspective StudiesBiomarkersChemokinesCytokinesbiomarkerscytokinespainsleep

Identifiers

PMID40649738
PMCPMC12249655

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.