CYP1A1/20-HETE/GPR75 Axis-Mediated Arachidonic Acid Metabolism Dysregulation in H-Type Hypertension Pathogenesis.

Hangyu Lv, Lingyun Liu, Baoling Bai, Kexin Zhang, Qin Zhang

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hangyu LvBeijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Children's Medical Center, Capital Medical University, Capital Institute of Pediatrics, Beijing 100020, China.

Lingyun LiuBeijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Children's Medical Center, Capital Medical University, Capital Institute of Pediatrics, Beijing 100020, China.

Baoling BaiBeijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Children's Medical Center, Capital Medical University, Capital Institute of Pediatrics, Beijing 100020, China.

Kexin ZhangBeijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Children's Medical Center, Capital Medical University, Capital Institute of Pediatrics, Beijing 100020, China.

Qin ZhangBeijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Children's Medical Center, Capital Medical University, Capital Institute of Pediatrics, Beijing 100020, China.

Funding

Capital Institute of Pediatrics CXYJ-2021-02the Beijing Natural Science Foundation 7232008 ,7222017the National Natural Science Foundation of China 82171652

6 · The paper itself

Abstract

This study aims to explore the pathogenic mechanism of H-type hypertension. A rat model of H-type hypertension was established through high-methionine dietary intervention, with subsequent folic acid administration. Untargeted serum metabolomic profiling identified a significant reduction in arachidonic acid (AA) levels in the methionine-enriched group, which were effectively normalized following folic acid supplementation. Transcriptomic analysis revealed methionine-induced upregulation of AA pathway-associated genes

Indexed as

Arachidonic AcidCytochrome P-450 CYP1A1Hydroxyeicosatetraenoic AcidsHypertensionReceptors, G-Protein-CoupledAnimalsDisease Models, AnimalHumansMaleMethionineRatsRats, Sprague-DawleySignal Transduction20-hydroxy-5,8,11,14-eicosatetraenoic acidArachidonic AcidCytochrome P-450 CYP1A1Hydroxyeicosatetraenoic AcidsMethionineReceptors, G-Protein-Coupled20-HETEarachidonic acidCYP1A1Gpr75homocysteineH-type hypertension

Identifiers

PMID40649725

DOI10.3390/ijms26135947

PMCPMC12249897

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.