Evidence map›Paper›PMID 40649714›Full record

ArticleInternational journal of molecular sciences2025

Parvalbumin Neurons in the Basal Forebrain Projecting to the Mammillary Nucleus Ameliorate Age-Related Cognitive Decline.

Tingting Sun, Qianqian Li, Bimin Liu, Jiale Chen, Anan Li, Tao Jiang, Hui Gong, Xiangning Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tingting SunMOE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China.ORCID 0009-0002-6250-2586
Qianqian LiMOE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China.
Bimin LiuKey Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Haikou 570228, China.
Jiale ChenMOE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China.
Anan LiMOE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China.
Tao JiangHUST-Suzhou Institute for Brainsmatics, JITRI, Suzhou 215125, China.ORCID 0000-0002-4487-299X
Hui GongMOE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China.
Xiangning LiKey Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Haikou 570228, China.ORCID 0000-0002-3747-2824

Funding

National Natural Science Foundation of China Nos. 32400931
6 · The paper itself

Abstract

Parvalbumin (PV) neurons in the basal forebrain (BF) orchestrate cognitive functions via extensive brain-wide projections. However, the age-related cognitive decline of their anatomical circuits remains poorly understood. Here, we employed viral tracing and fluorescence micro-optical sectioning tomography (fMOST) to reveal the vulnerability of the BF-PV circuits during aging. Quantitative whole-brain fluorescence intensity analysis revealed that BF-PV neurons projecting to the medial mammillary nucleus (MM) exhibited pronounced age-dependent neurodegeneration, characterized by 81.1% fiber loss and axonal swelling, while those innervating hippocampal CA1 showed a 70.3% reduction in fiber density. Optogenetic interventions demonstrated that selective activation of the BF

Indexed as

AgingBasal ForebrainCognitive DysfunctionMammillary BodiesNeuronsParvalbuminsAnimalsCA1 Region, HippocampalMaleMiceMice, Inbred C57BLOptogeneticsParvalbuminsbasal forebraincognitive declineparvalbumin neuronvulnerable circuit

Identifiers

PMID40649714
PMCPMC12250046

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.