Evidence map›Paper›PMID 40649704›Full record

ReviewInternational journal of molecular sciences2025

Metformin Degradation by Advanced Oxidation Processes: Performance, Limitations, and Environmental Concerns.

Jaime M Castañeda-Sánchez, Felipe de J Silerio-Vázquez, Ignacio Villanueva-Fierro, Juan Carlos García-Prieto, Luis A González-Burciaga, José B Proal-Nájera

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jaime M Castañeda-SánchezCIIDIR-Unidad Durango, Instituto Politécnico Nacional, Calle Sigma 119, Fracc. 20 de Noviembre II, Durango 34220, Durango, Mexico.
Felipe de J Silerio-VázquezCIIDIR-Unidad Durango, Instituto Politécnico Nacional, Calle Sigma 119, Fracc. 20 de Noviembre II, Durango 34220, Durango, Mexico.ORCID 0000-0003-3293-3342
Ignacio Villanueva-FierroCIIDIR-Unidad Durango, Instituto Politécnico Nacional, Calle Sigma 119, Fracc. 20 de Noviembre II, Durango 34220, Durango, Mexico.ORCID 0000-0001-7751-9271
Juan Carlos García-PrietoCentro de Investigación y Desarrollo Tecnológico del Agua, Universidad de Salamanca, Campo Charro s/n, 37080 Salamanca, Spain.ORCID 0000-0002-5572-1601
Luis A González-BurciagaCIIDIR-Unidad Durango, Instituto Politécnico Nacional, Calle Sigma 119, Fracc. 20 de Noviembre II, Durango 34220, Durango, Mexico.
José B Proal-NájeraCIIDIR-Unidad Durango, Instituto Politécnico Nacional, Calle Sigma 119, Fracc. 20 de Noviembre II, Durango 34220, Durango, Mexico.ORCID 0000-0001-6356-5998

Funding

Instituto Politécnico Nacional RFC: IPN811229H26; Miguel Othón de Mendizábal S/N, Col. La Escalera, Gustavo A. Madero, Ciudad de México 07320, México
6 · The paper itself

Abstract

This review provides a descriptive analysis of metformin, highlighting its environmental presence and classification as an emerging contaminant. It examines the risks associated with metformin and evaluates advanced oxidation processes (AOPs) for its degradation, including photolysis, photocatalysis, electrolysis, and ozonation. Metformin, a widely used biguanide for type 2 diabetes, is increasingly detected in aquatic environments due to its incomplete metabolism in humans, raising ecological concerns. While certain AOPs, such as ultraviolet (UV) photocatalysis and ozonation, achieve high degradation rates of 99.9% and 100%, respectively, they produce toxic by-products harmful to aquatic systems. Solar photocatalysis, despite a lower degradation rate (74.22%), stands out for operating without artificial energy and generating fewer hazardous by-products. The review identifies gaps in current degradation strategies and underscores the need for clean, sustainable methods. Future research directions include advancing biological and photocatalytic technologies to improve AOPs' efficiency while minimizing environmental risks.

Indexed as

MetforminWater Pollutants, ChemicalCatalysisHumansOxidation-ReductionOzonePhotolysisUltraviolet RaysMetforminOzoneWater Pollutants, Chemicaladvanced oxidation processesbiguanidesdiabetes mellitusemerging contaminantsmetformin degradationwastewater treatment

Identifiers

PMID40649704
PMCPMC12250226

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.