ReviewMaterials (Basel, Switzerland)2025
The Impact of Environmental and Material Factors on Fluoride Release from Metal-Modified Glass Ionomer Cements: A Systematic Review of In Vitro Studies.
Review in Materials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Functionalization Strategies of Chitosan-Based Scaffolds with Growth Factors for Bone Regeneration: A Systematic Review.Marine drugs · 2025Pooled it
- Effects of Additive Incorporation on Fluoride Release of Orthodontic Glass Ionomer Cements and Adhesives: A Systematic Review.Materials (Basel, Switzerland) · 2026Review
- Effect of Titanium Dioxide (TiOMaterials (Basel, Switzerland) · 2026Review
- Strategies for Enhancing Conventional Glass Ionomer Cement-A Short Review.Materials (Basel, Switzerland) · 2026Review
- Evaluation of Factors Affecting Fluoride Release from Dental Sealants: A Systematic Review.Materials (Basel, Switzerland) · 2025Review
- Evaluation of Factors Affecting Fluoride Release from Fluoride Varnishes: A Systematic Review.Materials (Basel, Switzerland) · 2025Review
- Enhancing Osseointegration of Zirconia Implants Using Calcium Phosphate Coatings: A Systematic Review.Materials (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveFluoride is widely recognized for its preventive role against secondary caries. This systematic review aimed to evaluate how environmental and material factors influence fluoride ion release from metal-reinforced glass ionomer cements.
methodsA structured literature search was performed in March 2025 across PubMed, Scopus, and Web of Science databases. Search terms included combinations of fluoride release AND glass ionomer AND silver OR zinc OR strontium OR copper. The study selection process followed PRISMA 2020 guidelines and was organized using the PICO framework. Out of 281 initially identified records, 153 were screened based on titles and abstracts. After applying predefined eligibility criteria, 23 studies met the inclusion requirements and were included in the qualitative analysis.
resultsAmong the 23 included publications, 12 involved glass ionomers modified with silver, and 6 of these reported an increase in fluoride release. Seven studies focused on zinc-modified cements, and four examined materials reinforced with strontium.
conclusionsThe addition of strontium, titanium oxide, silver nanoparticles, or zirconium oxide increases the release of fluoride ions, while sintered silver reduces it. There is a great discrepancy among researchers regarding the effect of the addition of zinc oxide and its appropriate amount in the glass ionomer material.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.