ArticleMolecules (Basel, Switzerland)2025
Revealing Serotonin Derivatives in Safflower Seed Meal as Potential Anti-Ulcerative Colitis Drugs: In Vitro and Computational Evidence.
Liang Zhang, Md Hasan Ali, Chao Jiang, Furong Fan, Furong Zhu, Yating Lu, Mengwei Jia, Haipeng Yin, Jianwang Wei, Dongsen Wu and 2 more
Abstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
12 authors.
Liang ZhangKey Laboratory of Xinjiang Phytomedicine Resource and Utilisation, Ministry of Education, Institute for Safflower Industry Research, Pharmacy College, Collaborative Innovation Center for Efficient Safflower Production and Resource Utilization, Shihezi University, North 4th Road 221, Shihezi 832002, China.ORCID 0009-0007-0544-6940 Md Hasan AliKey Laboratory of Xinjiang Phytomedicine Resource and Utilisation, Ministry of Education, Institute for Safflower Industry Research, Pharmacy College, Collaborative Innovation Center for Efficient Safflower Production and Resource Utilization, Shihezi University, North 4th Road 221, Shihezi 832002, China.ORCID 0009-0004-7481-969X Chao JiangKey Laboratory of Xinjiang Phytomedicine Resource and Utilisation, Ministry of Education, Institute for Safflower Industry Research, Pharmacy College, Collaborative Innovation Center for Efficient Safflower Production and Resource Utilization, Shihezi University, North 4th Road 221, Shihezi 832002, China.ORCID 0009-0000-8799-1449 Furong FanKey Laboratory of Xinjiang Phytomedicine Resource and Utilisation, Ministry of Education, Institute for Safflower Industry Research, Pharmacy College, Collaborative Innovation Center for Efficient Safflower Production and Resource Utilization, Shihezi University, North 4th Road 221, Shihezi 832002, China.ORCID 0009-0001-9512-0704 Furong ZhuKey Laboratory of Xinjiang Phytomedicine Resource and Utilisation, Ministry of Education, Institute for Safflower Industry Research, Pharmacy College, Collaborative Innovation Center for Efficient Safflower Production and Resource Utilization, Shihezi University, North 4th Road 221, Shihezi 832002, China.ORCID 0009-0008-1504-2592 Yating LuKey Laboratory of Xinjiang Phytomedicine Resource and Utilisation, Ministry of Education, Institute for Safflower Industry Research, Pharmacy College, Collaborative Innovation Center for Efficient Safflower Production and Resource Utilization, Shihezi University, North 4th Road 221, Shihezi 832002, China.ORCID 0009-0003-0798-4532 Mengwei JiaKey Laboratory of Xinjiang Phytomedicine Resource and Utilisation, Ministry of Education, Institute for Safflower Industry Research, Pharmacy College, Collaborative Innovation Center for Efficient Safflower Production and Resource Utilization, Shihezi University, North 4th Road 221, Shihezi 832002, China.ORCID 0009-0003-4348-5378 Haipeng YinKey Laboratory of Xinjiang Phytomedicine Resource and Utilisation, Ministry of Education, Institute for Safflower Industry Research, Pharmacy College, Collaborative Innovation Center for Efficient Safflower Production and Resource Utilization, Shihezi University, North 4th Road 221, Shihezi 832002, China.ORCID 0009-0005-9271-8363 Jianwang WeiKey Laboratory of Xinjiang Phytomedicine Resource and Utilisation, Ministry of Education, Institute for Safflower Industry Research, Pharmacy College, Collaborative Innovation Center for Efficient Safflower Production and Resource Utilization, Shihezi University, North 4th Road 221, Shihezi 832002, China.ORCID 0009-0005-2048-8140 Dongsen WuKey Laboratory of Xinjiang Phytomedicine Resource and Utilisation, Ministry of Education, Institute for Safflower Industry Research, Pharmacy College, Collaborative Innovation Center for Efficient Safflower Production and Resource Utilization, Shihezi University, North 4th Road 221, Shihezi 832002, China.ORCID 0009-0001-6195-4145 Shenghui ChuKey Laboratory of Xinjiang Phytomedicine Resource and Utilisation, Ministry of Education, Institute for Safflower Industry Research, Pharmacy College, Collaborative Innovation Center for Efficient Safflower Production and Resource Utilization, Shihezi University, North 4th Road 221, Shihezi 832002, China.ORCID 0000-0002-8163-1212 Min LiuKey Laboratory of Xinjiang Phytomedicine Resource and Utilisation, Ministry of Education, Institute for Safflower Industry Research, Pharmacy College, Collaborative Innovation Center for Efficient Safflower Production and Resource Utilization, Shihezi University, North 4th Road 221, Shihezi 832002, China.ORCID 0009-0001-5171-579X Funding
Guiding Science and Technology Program of XPCC 2022ZD049,2022ZD005Science and Technology Program System - National Natural Science Foundation General Project for Cultivation MSPY202406Shihezi University International Science and Technology Cooperation Promotion Program Project GJHZ202209The central government guides local funds of XPCC 2024YD008The National Natural Science Foundation of China grants 82260817,82160121
6 · The paper itselfAbstract
This study evaluated the in vitro anti-inflammatory activity of serotonin derivatives from safflower seed powder and elucidated their mechanism against ulcerative colitis using network pharmacology. Compounds were extracted and purified via silica gel column chromatography, Sephadex LH-20 and semi-preparative HPLC. Structural characterization employed NMR and UPLC-Q-TOF-MS/MS with literature comparisons. Anti-inflammatory efficacy was assessed in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. Network pharmacology predicted targets, molecular docking analyzed binding interactions and molecular dynamics simulations assessed complex stability. Eleven serotonin derivatives were isolated; N-trans-Feruloyl-3,5-dihydroxyindolin-2-one (
Indexed as
Anti-Inflammatory AgentsCarthamus tinctoriusColitis, UlcerativeSeedsSerotoninAnimalsLipopolysaccharidesMiceMolecular Docking SimulationMolecular Dynamics SimulationNetwork PharmacologyRAW 264.7 CellsSignal TransductionAnti-Inflammatory AgentsLipopolysaccharidesSerotoninmolecular dockingmolecular dynamics simulationnetwork pharmacologysafflower seed mealserotonin derivativesulcerative colitis
Identifiers
PMID40649400
PMCPMC12251380
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