Evidence map›Paper›PMID 40649394›Full record

ArticleMolecules (Basel, Switzerland)2025

Synthesis of Novel Tetra-Substituted Pyrazole Derivatives Using Microwave Irradiation and Their Anti-Leukemic Activity Against Jurkat Cells.

Felipe P Machado, Maria Clara Campos, Juliana Echevarria-Lima, Diego P Sangi, Carlos Serpa, Otávio Augusto Chaves, Aurea Echevarria

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Felipe P MachadoDepartment of Organic Chemistry, Institute of Chemistry, Federal Rural University of Rio de Janeiro, Seropédica 23897-000, RJ, Brazil.
Maria Clara CamposPaulo de Góes Institute of Microbiology, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.ORCID 0000-0003-1688-1781
Juliana Echevarria-LimaPaulo de Góes Institute of Microbiology, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.ORCID 0000-0002-0725-0198
Diego P SangiInstitute of Exact Sciences, Fluminense Federal University, Volta Redonda 27213-145, RJ, Brazil.ORCID 0000-0003-0388-5409
Carlos SerpaDepartment of Chemistry, Coimbra Chemistry Centre-Institute of Molecular Science, University of Coimbra, Rua Larga, 3004-535 Coimbra, Portugal.
Otávio Augusto ChavesDepartment of Chemistry, Coimbra Chemistry Centre-Institute of Molecular Science, University of Coimbra, Rua Larga, 3004-535 Coimbra, Portugal.ORCID 0000-0001-6211-7659
Aurea EchevarriaDepartment of Organic Chemistry, Institute of Chemistry, Federal Rural University of Rio de Janeiro, Seropédica 23897-000, RJ, Brazil.ORCID 0000-0002-7330-676X

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 001Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro 211.627/2021Fundação para a Ciência e Tecnologia UIDB/00313/2025 and UIDP/00313/2025National Council for Scientific and Technological Development 30864/2019-2
6 · The paper itself

Abstract

Three previously synthesized ketene dithioacetals were used as intermediates to obtain four nucleophiles to synthesize ten tetra-substituted pyrazoles (

Indexed as

Antineoplastic AgentsLeukemiaMicrowavesPyrazolesAnimalsCell SurvivalHumansJurkat CellsMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAntineoplastic AgentspyrazolePyrazolesdithioacetalsin-silico predictionsJurkat cellsketeneleukemiamicrowave-assistedpyrazole

Identifiers

PMID40649394
PMCPMC12251036

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.