Evidence map›Paper›PMID 40649387›Full record

ArticleMolecules (Basel, Switzerland)2025

Exploring the Potential of a New Nickel(II):Phenanthroline Complex with L-isoleucine as an Antitumor Agent: Design, Crystal Structure, Spectroscopic Characterization, and Theoretical Insights.

Jayson C Dos Santos, João G de Oliveira Neto, Ana B N Moreira, Luzeli M da Silva, Alejandro P Ayala, Mateus R Lage, Rossano Lang, Francisco F de Sousa, Fernando Mendes, Adenilson O Dos Santos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jayson C Dos SantosCenter for Sciences of Imperatriz, Federal University of Maranhão-UFMA, Imperatriz 65900-410, MA, Brazil.ORCID 0009-0003-7949-9034
João G de Oliveira NetoCenter for Sciences of Imperatriz, Federal University of Maranhão-UFMA, Imperatriz 65900-410, MA, Brazil.
Ana B N MoreiraCenter for Sciences of Imperatriz, Federal University of Maranhão-UFMA, Imperatriz 65900-410, MA, Brazil.ORCID 0000-0003-3153-9423
Luzeli M da SilvaCenter for Sciences of Imperatriz, Federal University of Maranhão-UFMA, Imperatriz 65900-410, MA, Brazil.ORCID 0000-0002-7233-0776
Alejandro P AyalaDepartment of Physics, Federal University of Ceará-UFC, Fortaleza 65455-900, CE, Brazil.ORCID 0000-0002-9247-6780
Mateus R LageCenter for Sciences of Imperatriz, Federal University of Maranhão-UFMA, Imperatriz 65900-410, MA, Brazil.ORCID 0000-0002-4810-0479
Rossano LangInstitute of Science and Technology, Federal University of São Paulo-UNIFESP, São José dos Campos 12231-280, SP, Brazil.ORCID 0000-0001-6499-4700
Francisco F de SousaInstitute of Exact and Natural Sciences, Federal University of Para-UFPA, Belém 66075-110, PA, Brazil.
Fernando MendesDepartment Biomedical Laboratory Sciences, ESTEC-Coimbra Health School, Polytechnic Institute of Coimbra, 3046-854 Coimbra, Portugal.ORCID 0000-0002-5205-8939
Adenilson O Dos SantosCenter for Sciences of Imperatriz, Federal University of Maranhão-UFMA, Imperatriz 65900-410, MA, Brazil.ORCID 0000-0002-2248-5104

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study presents the synthesis, physicochemical characterization, and biological evaluation of a novel ternary nickel(II) complex with isoleucine and 1,10-phenanthroline ligands, [Ni(Phen)(Ile)

Indexed as

Antineoplastic AgentsCoordination ComplexesIsoleucineNickelPhenanthrolinesCell Line, TumorCrystallography, X-RayDensity Functional TheoryDrug DesignHumansHydrogen BondingLigandsModels, MolecularMolecular Structure1,10-phenanthrolineAntineoplastic AgentsCoordination ComplexesIsoleucineLigandsNickelPhenanthrolinescrystal growthcytotoxicityDFT calculationsHirshfeld surfacesnickel(II) complexvibrational spectroscopy

Identifiers

PMID40649387
PMCPMC12251309

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.