Evidence map›Paper›PMID 40649381›Full record

ArticleMolecules (Basel, Switzerland)2025

Vasodilator Effects of Quercetin 3-O-Malonylglucoside Are Mediated by the Activation of Endothelial Nitric Oxide Synthase and the Opening of Large-Conductance Calcium-Activated K

Maria Luiza Fidelis da Silva, Erdi Can Aytar, Arquimedes Gasparotto Junior

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Maria Luiza Fidelis da SilvaLaboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados 79.804-070, MS, Brazil.
Erdi Can AytarDepartment of Horticulture, Faculty of Agriculture, Usak University, 64200 Uşak, Türkiye.ORCID 0000-0001-6045-0183
Arquimedes Gasparotto JuniorLaboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados 79.804-070, MS, Brazil.ORCID 0000-0003-3433-5098

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior noneFundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul 71/700.135/2018; 83/013.186/2023National Council for Scientific and Technological Development 407685/2018-9; 150258/2023-2
6 · The paper itself

Abstract

We used molecular docking as a computational tool to predict the binding affinities and interactions of quercetin 3-O-malonylglucoside (Q3MG) with vascular target proteins. First, the proteins 1M9M (human endothelial nitric oxide synthase; eNOS) and 6ND0 (human large-conductance voltage- and calcium-activated K

Indexed as

HypertensionLarge-Conductance Calcium-Activated Potassium ChannelsNitric Oxide Synthase Type IIIQuercetinVasodilator AgentsAnimalsEndothelium, VascularHumansLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsMaleMesenteric ArteriesMolecular Docking SimulationRatsRats, Inbred SHRVasodilationLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsLarge-Conductance Calcium-Activated Potassium ChannelsNitric Oxide Synthase Type IIIQuercetinVasodilator AgentsflavoneK+ channelsmesenteric vascular bedvasodilation

Identifiers

PMID40649381
PMCPMC12251491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.