Evidence map›Paper›PMID 40649358›Full record

ArticleMolecules (Basel, Switzerland)2025

Cytotoxic Activity of Essential Oils from Middle Eastern Medicinal Plants on Malignant Keratinocytes.

Rima Othman, Vanessa Moarbes, Muriel Tahtouh Zaatar, Diane Antonios, Rabih Roufayel, Marc Beyrouthy, Ziad Fajloun, Jean-Marc Sabatier, Marc Karam

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Nanosponge-integrated hydrogel ofFrontiers in pharmacology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rima OthmanDepartment of Pulmonary Medicine and Critical Care, Johns Hopkins University, Baltimore, MD 21205, USA.
Vanessa MoarbesDepartment of Biology, Faculty of Sciences, University of Balamand, Al-Kourah, Tripoli P.O. Box 100, Lebanon.
Muriel Tahtouh ZaatarDepartment of Biological and Physical Sciences, American University in Dubai, Dubai P.O. Box 28282, United Arab Emirates.
Diane AntoniosLaboratory of Toxicology, Faculty of Pharmacy, Saint Joseph University of Beirut, Damascus Road, Beirut P.O. Box 11-5076, Lebanon.ORCID 0000-0003-2740-1640
Rabih RoufayelCollege of Engineering and Technology, American University of the Middle East, Egaila 54200, Kuwait.ORCID 0000-0002-4595-1104
Marc BeyrouthyDepartment of Agriculture and Food Engineering, School of Engineering, Holy Spirit University of Kaslik, Jounieh P.O. Box 446, Lebanon.
Ziad FajlounDepartment of Cell Culture, Laboratory of Applied Biotechnology (LBA3B), Azm Center for Research in Biotechnology and Its Applications, EDST, Lebanese University, Tripoli 1300, Lebanon.ORCID 0000-0002-6502-3110
Jean-Marc SabatierInst Neurophysiopathol (INP), CNRS, Aix-Marseille Université, 13385 Marseille, France.ORCID 0000-0002-9040-5647
Marc KaramDepartment of Biology, Faculty of Sciences, University of Balamand, Al-Kourah, Tripoli P.O. Box 100, Lebanon.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skin cancer, including melanoma and non-melanoma cancers (basal and squamous cell carcinomas), is the most common type of cancer. UV radiation, family history, and genetic predisposition are the main risk factors. Although surgical excision is the standard treatment, essential oils are attracting growing interest for their anti-cancer effects. This study tested the effects of

Indexed as

Antineoplastic Agents, PhytogenicKeratinocytesOils, VolatilePlants, MedicinalSkin NeoplasmsCell Line, TumorCell ProliferationCell SurvivalHumansMiddle EastAntineoplastic Agents, PhytogenicOils, VolatileA5 cell linesanti-cancer effectessential oilHaCatII4 cell linesJuniperus excelsa M. Bieb. (Cupressaceae)Lavandula vera DC. (Lamiaceae)MTT assaySalvia fruticosa Mill. (Lamiaceae)

Identifiers

PMID40649358
PMCPMC12250990

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.