Evidence map›Paper›PMID 40649319›Full record

ArticleMolecules (Basel, Switzerland)2025

Engineering a Radiohybrid PSMA Ligand with an Albumin-Binding Moiety and Pharmacokinetic Modulation via an Albumin-Binding Competitor for Radiotheranostics.

Saki Hirata, Hiroaki Echigo, Masayuki Munekane, Kenji Mishiro, Kohshin Washiyama, Takeshi Fuchigami, Hiroshi Wakabayashi, Kazuhiro Takahashi, Seigo Kinuya, Kazuma Ogawa

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Saki HirataGraduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Ishikawa, Japan.
Hiroaki EchigoGraduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Ishikawa, Japan.
Masayuki MunekaneGraduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Ishikawa, Japan.ORCID 0000-0002-3405-4512
Kenji MishiroGraduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Ishikawa, Japan.ORCID 0000-0002-5071-7574
Kohshin WashiyamaAdvanced Clinical Research Center, Fukushima Global Medical Science Center, Fukushima Medical University, 1 Hikarigaoka, Fukushima 960-1295, Fukushima, Japan.ORCID 0000-0002-9908-8756
Takeshi FuchigamiGraduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Ishikawa, Japan.ORCID 0000-0001-8141-1212
Hiroshi WakabayashiDepartment of Nuclear Medicine, Kanazawa University Hospital, Kanazawa University, Takara-machi 13-1, Kanazawa 920-8641, Ishikawa, Japan.
Kazuhiro TakahashiAdvanced Clinical Research Center, Fukushima Global Medical Science Center, Fukushima Medical University, 1 Hikarigaoka, Fukushima 960-1295, Fukushima, Japan.ORCID 0000-0001-7855-575X
Seigo KinuyaDepartment of Nuclear Medicine, Kanazawa University Hospital, Kanazawa University, Takara-machi 13-1, Kanazawa 920-8641, Ishikawa, Japan.
Kazuma OgawaGraduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Ishikawa, Japan.ORCID 0000-0002-1691-7302

Funding

JSPS KAKENHI JP21H02867 and JP24K02394Program of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Sci-ence NoTerumo life science foundation NoThe Mitani Foundation for Research and Development No
6 · The paper itself

Abstract

The prostate-specific membrane antigen (PSMA) is a well-established target for radiotheranostics in prostate cancer. We previously demonstrated that 4-(

Indexed as

AlbuminsAntigens, SurfaceGlutamate Carboxypeptidase IIProstatic NeoplasmsRadiopharmaceuticalsAnimalsAstatineCell Line, TumorDipeptidesHeterocyclic Compounds, 1-RingHumansIodine RadioisotopesLigandsMaleMiceProstate-Specific AntigenAlbuminsAntigens, SurfaceAstatineAstatine-211DipeptidesFOLH1 protein, humanGlutamate Carboxypeptidase IIHeterocyclic Compounds, 1-RingIodine RadioisotopesLigandsProstate-Specific AntigenPSMA-617Radiopharmaceuticalsalbumin-binding moietyastatine-211PSMAradiotheranosticstargeted alpha therapy (TAT)

Identifiers

PMID40649319
PMCPMC12251549

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.