Evidence map›Paper›PMID 40649306›Full record

ArticleMolecules (Basel, Switzerland)2025

Synthesis of Novel 7-Phenyl-2,3-Dihydropyrrolo[2,1-

Davron Turgunov, Lifei Nie, Azizbek Nasrullaev, Zarifa Murtazaeva, Bianlin Wang, Dilafruz Kholmurodova, Rustamkhon Kuryazov, Jiangyu Zhao, Khurshed Bozorov, Haji Akber Aisa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Thieno[3,2-International journal of molecular sciences · 2026
    Review
  2. Design, synthesis, and activity study of heterocyclic derivatives as JAK inhibitors.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Article
  3. Article
  4. Scaffold-Hopping Design and Synthesis of Thieno[3,2-International journal of molecular sciences · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Davron TurgunovDepartment of Organic Synthesis and Bioorganic Chemistry, Institute of Biochemistry, Samarkand State University, University Blvd. 15, Samarkand 140104, Uzbekistan.
Lifei NieState Key Laboratory Basis of Xinjiang Indigenous Míicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, South Beijing Rd 40-1, Urumqi 830011, China.
Azizbek NasrullaevDepartment of Organic Synthesis and Bioorganic Chemistry, Institute of Biochemistry, Samarkand State University, University Blvd. 15, Samarkand 140104, Uzbekistan.
Zarifa MurtazaevaDepartment of Organic Synthesis and Bioorganic Chemistry, Institute of Biochemistry, Samarkand State University, University Blvd. 15, Samarkand 140104, Uzbekistan.
Bianlin WangState Key Laboratory Basis of Xinjiang Indigenous Míicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, South Beijing Rd 40-1, Urumqi 830011, China.
Dilafruz KholmurodovaScientific and Practical Center of Immunology, Allergology and Human Genomics, Samarkand State Medical University, Makhdum-i A'ẓam st. 18, Samarkand 140104, Uzbekistan.
Rustamkhon KuryazovDepartment of Chemistry, Urgench State University, Kh. Olimjon st. 14, Urgench 220100, Uzbekistan.
Jiangyu ZhaoState Key Laboratory Basis of Xinjiang Indigenous Míicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, South Beijing Rd 40-1, Urumqi 830011, China.
Khurshed BozorovDepartment of Organic Synthesis and Bioorganic Chemistry, Institute of Biochemistry, Samarkand State University, University Blvd. 15, Samarkand 140104, Uzbekistan.ORCID 0000-0001-7449-0936
Haji Akber AisaState Key Laboratory Basis of Xinjiang Indigenous Míicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, South Beijing Rd 40-1, Urumqi 830011, China.ORCID 0000-0003-4652-6879

Funding

Chinese Academy of Sciences President's International Fellowship Initiative No. 2024VBA0021Organization of the Laboratory for the Creation of anticancer drugs" No. ALM-202310062530
6 · The paper itself

Abstract

An important field of research in medicinal and organic chemistry involves halogen-containing heterocyclic synthones, which form the backbone of more complex organic compounds. This study aimed to design and synthesize 28 novel derivatives of 7-aryl-2,3-dihydropyrrolo[2,1-

Indexed as

Alzheimer DiseaseCholinesterase InhibitorsQuinazolinonesAcetylcholinesteraseButyrylcholinesteraseHumansMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAcetylcholinesteraseButyrylcholinesteraseCholinesterase InhibitorsQuinazolinonesAcetylcholinesterase (AChE)Alzheimer’s diseaseButyrylcholinesterase (BChE)carbon–carbon bond (C-C)deoxyvasicinonemackinazolinonePd catalystquinazolineSuzuki–Miyaura cross-coupling

Identifiers

PMID40649306
PMCPMC12250785

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.