Evidence map›Paper›PMID 40649273›Full record

ArticleMolecules (Basel, Switzerland)2025

The Structural Basis of Binding Stability and Selectivity of Sarolaner Enantiomers for

Xiaojiao Zheng, Xin Wang, Xiulian Ju, Zhichao Ma, Genyan Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiaojiao ZhengHubei Provincial Engineering Research Center of Racing Horse Detection and Application Transformation, Equine Science Research and Horse Doping Control Laboratory, School of Physical Education, Wuhan Business University, Wuhan 430056, China.ORCID 0009-0002-6589-1652
Xin WangHubei Provincial Engineering Research Center of Racing Horse Detection and Application Transformation, Equine Science Research and Horse Doping Control Laboratory, School of Physical Education, Wuhan Business University, Wuhan 430056, China.
Xiulian JuHubei Key Laboratory of Novel Reactor and Green Chemical Technology, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan 430205, China.
Zhichao MaHubei Provincial Engineering Research Center of Racing Horse Detection and Application Transformation, Equine Science Research and Horse Doping Control Laboratory, School of Physical Education, Wuhan Business University, Wuhan 430056, China.
Genyan LiuHubei Key Laboratory of Novel Reactor and Green Chemical Technology, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan 430205, China.

Funding

The National Natural Science Foundation of China No. 22177090 and 21807082The Science and Technology Research Project of Hubei Provincial Department of Education D20221503
6 · The paper itself

Abstract

The ionotropic γ-aminobutyric acid (GABA) receptor (GABAR) is a key target for the development of antiparasitic agents, particularly against ectoparasites, such as fleas and ticks. Binding stability and selectivity of sarolaner enantiomers for

Indexed as

CtenocephalidesReceptors, GABAAnimalsBinding SitesHydrogen BondingMolecular Docking SimulationMolecular Dynamics SimulationProtein BindingStereoisomerismReceptors, GABAGABA receptormolecular dockingmolecular dynamics simulationsmolecular mechanismssarolaner

Identifiers

PMID40649273
PMCPMC12250689

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.