Evidence map›Paper›PMID 40649237›Full record

ArticleMolecules (Basel, Switzerland)2025

Degradation of Folic Acid in the Composition of a Conjugate with Polyvinylpyrrolidone and Fullerene C

Alina A Borisenkova, Dmitriy V Baykov, Anna V Titova, Vadim V Bakhmetyev, Maria A Markova, Zhanna B Lyutova, Anton V Popugaev, Vladislav S Khaleev, Victor P Sedov

Abstract read
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In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alina A BorisenkovaRadiation Technology Department, St. Petersburg State Institute of Technology (Technical University), 190013 St. Petersburg, Russia.ORCID 0000-0002-7618-5617
Dmitriy V BaykovRadiation Technology Department, St. Petersburg State Institute of Technology (Technical University), 190013 St. Petersburg, Russia.
Anna V TitovaRadiation Technology Department, St. Petersburg State Institute of Technology (Technical University), 190013 St. Petersburg, Russia.
Vadim V BakhmetyevDepartment of Theory of Materials Science, St. Petersburg State Institute of Technology (Technical University), 190013 St. Petersburg, Russia.
Maria A MarkovaRadiation Technology Department, St. Petersburg State Institute of Technology (Technical University), 190013 St. Petersburg, Russia.
Zhanna B LyutovaRadiation Technology Department, St. Petersburg State Institute of Technology (Technical University), 190013 St. Petersburg, Russia.
Anton V PopugaevRadiation Technology Department, St. Petersburg State Institute of Technology (Technical University), 190013 St. Petersburg, Russia.
Vladislav S KhaleevInfochemistry Scientific Center, ITMO University, 191002 St. Petersburg, Russia.ORCID 0009-0007-9741-7783
Victor P SedovPetersburg Nuclear Physics Institute named by B.P. Konstantinov of National Research Centre "Kurchatov Institute", 188300 Gatchina, Russia.

Funding

Russian Science Foundation 23-73-01085
6 · The paper itself

Abstract

Folic acid (FA) is used as a targeting ligand for targeted drug delivery to tumor cells, some types of which overexpress folate receptors on their surface. However, while the preparation of conjugates containing FA may comprise a multi-step process, FA presents low photostability under UV irradiation. In addition, FA undergoes radiolysis under the action of ionizing radiation, which is utilized for drug sterilization. In this study, we investigate the stability of FA in a conjugate (FA-PVP-C

Indexed as

folic acidfullerenephotodegradationradiation chemical yieldradiolysisUV irradiation

Identifiers

PMID40649237
PMCPMC12251273

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.