Hybrid Uracil Derivatives with Caffeine and Gramine Obtained via Click Chemistry as Potential Antioxidants and Inhibitors of Plant Pathogens.

Milda Szlaużys, Kamil Ostrowski, Damian Nowak, Wiesław Prukała, Justyna Starzyk, Beata Jasiewicz, Lucyna Mrówczyńska

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Ferrocenoylation of Uracil Derivatives: Study of Reaction Regioselectivity and Biological Activity.Molecules (Basel, Switzerland) · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Milda SzlaużysDepartment of Bioactive Products, Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland.

Kamil OstrowskiDepartment of Bioactive Products, Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland.

Damian NowakDepartment of Quantum Chemistry, Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland.ORCID 0000-0003-3739-3306

Wiesław PrukałaDepartment of Natural Products, Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland.ORCID 0000-0001-9894-5771

Justyna StarzykDepartment of Soil Science and Microbiology, Faculty of Agronomy, Horticulture, and Bioengineering, University of Life Science, Szydłowska 50, 60-656 Poznań, Poland.

Beata JasiewiczDepartment of Bioactive Products, Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland.ORCID 0000-0002-6741-473X

Lucyna MrówczyńskaDepartment of Cell Biology, Faculty of Biology, Adam Mickiewicz University, Uniwersytetu Poznańskiego 6, 61-614 Poznań, Poland.ORCID 0000-0002-4425-5596

Funding

ID-UB 054/13/SNŚ/0007

6 · The paper itself

Abstract

A series of novel hybrid uracil derivatives incorporating the natural alkaloids caffeine or gramine, linked via 1,2,3-triazole ring, were synthetized using click chemistry. The structures of the obtained compounds were confirmed by spectroscopic methods, including

Indexed as

Antifungal AgentsAntioxidantsCaffeineUracilAnti-Bacterial AgentsBotrytisClick ChemistryFusariumMicrobial Sensitivity TestsMolecular Docking SimulationMolecular StructureOxidative StressStructure-Activity RelationshipAnti-Bacterial AgentsAntifungal AgentsAntioxidantsCaffeineUracil1,2,3-triazoleantifungal propertiesantioxidant activitycaffeineclick chemistrygraminehuman erythrocytesoxidative stressuracil derivatives

Identifiers

PMID40649234

DOI10.3390/molecules30132714

PMCPMC12251463

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.