Evidence map›Paper›PMID 40649206›Full record

ArticleMolecules (Basel, Switzerland)2025

Novel Azole-Modified Porphyrins for Mitochondria-Targeted Photodynamic Therapy.

Sabarinathan Rangasamy, Elisa Bandini, Alessandro Venturini, Giuseppina Bozzuto, Sofia Migani, Annarica Calcabrini, Simona Sennato, Caterina Zuffa, Lucia Maini, Anaïs Brion and 3 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sabarinathan RangasamyInstitute for Organic Synthesis and Photoreactivity (ISOF), National Research Council of Italy (CNR), Via P. Gobetti 101, I-40129 Bologna, Italy.ORCID 0000-0001-8446-095X
Elisa BandiniInstitute for Organic Synthesis and Photoreactivity (ISOF), National Research Council of Italy (CNR), Via P. Gobetti 101, I-40129 Bologna, Italy.ORCID 0000-0001-7222-3789
Alessandro VenturiniInstitute for Organic Synthesis and Photoreactivity (ISOF), National Research Council of Italy (CNR), Via P. Gobetti 101, I-40129 Bologna, Italy.
Giuseppina BozzutoNational Centre for Drug Research and Evaluation, Italian National Institute of Health, Viale Regina Elena 299, I-00161 Rome, Italy.ORCID 0000-0002-9761-3326
Sofia MiganiNational Centre for Drug Research and Evaluation, Italian National Institute of Health, Viale Regina Elena 299, I-00161 Rome, Italy.
Annarica CalcabriniNational Centre for Drug Research and Evaluation, Italian National Institute of Health, Viale Regina Elena 299, I-00161 Rome, Italy.ORCID 0000-0002-9600-1117
Simona SennatoInstitute for Complex Systems (ISC), National Research Council of Italy (CNR) and Physics Department, Sapienza University of Rome, Piazzale A. Moro 5, I-00185 Rome, Italy.ORCID 0000-0003-4793-5359
Caterina ZuffaDepartment of Chemistry "Giacomo Ciamician", University of Bologna, Via F. Selmi 2, I-40126 Bologna, Italy.ORCID 0000-0002-7150-3292
Lucia MainiDepartment of Chemistry "Giacomo Ciamician", University of Bologna, Via F. Selmi 2, I-40126 Bologna, Italy.ORCID 0000-0002-0703-2617
Anaïs BrionLaboratory of Synthetic and Therapeutic Chemo-Biology, UMR 7199, University of Strasbourg/CNRS, Faculty of Pharmacy, F-67401 Illkirch, Cedex, France.
Frédéric BolzeLaboratory of Synthetic and Therapeutic Chemo-Biology, UMR 7199, University of Strasbourg/CNRS, Faculty of Pharmacy, F-67401 Illkirch, Cedex, France.ORCID 0000-0002-7955-4668
Cecilia BombelliInstitute for Biological Systems (ISB), National Research Council of Italy (CNR), Secondary Office of Rome-Reaction Mechanisms c/o Department of Chemistry, Sapienza University of Rome, Piazzale A. Moro 5, I-00185 Rome, Italy.ORCID 0000-0003-0877-0504
Barbara VenturaInstitute for Organic Synthesis and Photoreactivity (ISOF), National Research Council of Italy (CNR), Via P. Gobetti 101, I-40129 Bologna, Italy.ORCID 0000-0002-8207-1659

Funding

H2020-MSCA-IF-2017 798952National Research Council Photo-Induced Processes (LIP)
6 · The paper itself

Abstract

Photodynamic therapy is a non-invasive treatment strategy for various types of cancer, based on the use of light to activate a photosensitizer which triggers processes leading to cell death. Given the increasing interest in the development of mitochondria-targeted photosensitizers, in this study we synthesized two novel thiadiazol-substituted porphyrins, 5,10,15,20-tetra(2,1,3-benzothiadiazol-5-yl) porphyrin (

Indexed as

AzolesMitochondriaPhotochemotherapyPhotosensitizing AgentsPorphyrinsCell Line, TumorCell SurvivalHumansSinglet OxygenAzolesPhotosensitizing AgentsPorphyrinsSinglet Oxygenazolemitochondriaphotodynamic therapyporphyrins

Identifiers

PMID40649206
PMCPMC12250747

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.