Evidence map›Paper›PMID 40648892›Full record

ReviewJournal of clinical medicine2025

Diagnosis and Diagnostic Challenges of Secondary Mitral Regurgitation in the Era of Transcatheter Edge-to-Edge Repair of the Mitral Valve.

Yusef B Saeed, Kyra Deep, Andreas Hagendorff, Bhupendar Tayal

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yusef B SaeedCleveland Medical Center, University Hospitals, Cleveland, OH 44106, USA.ORCID 0000-0003-4410-6125
Kyra DeepCleveland Medical Center, University Hospitals, Cleveland, OH 44106, USA.
Andreas HagendorffDepartment of Cardiology, Leipzig University Hospital, 04103 Leipzig, Germany.
Bhupendar TayalDivision of Cardiology, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR 72223, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Secondary mitral regurgitation (sMR) is commonly understood to be secondary to heart failure (HF), left ventricular (LV) dilation, and altered coaptation of the mitral annulus. Three forms of sMR exist: non-ischemic sMR, ischemic sMR, and atrial functional sMR. In the past, there have been limited treatment options for this condition besides medication. Recently, the management of sMR has been revolutionized by the recent advances in percutaneous transcatheter edge-to-edge repair of the mitral valve (m-TEER). However, the major trials investigating this technology have shown that appropriate patient selection is of critical importance to achieve benefit. As such, there is a renewed interest in the accurate diagnosis of sMR. Herein, we review the etiology, management, and diagnosis of sMR in the era m-TEER.

Indexed as

atrial functional mitral regurgitationcardiac magnetic resonance imagingechocardiographyheart failureMitraClipquantitative methodssecondary mitral regurgitationsemiquantitative methodstranscatheter edge-to-edge repair of the mitral valveventricular functional mitral regurgitation

Identifiers

PMID40648892
PMCPMC12250455

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.