Evidence map›Paper›PMID 40648884›Full record

ArticleJournal of clinical medicine2025

Recombinant IgG1 Fc-μTP-L309C Ameliorates Endogenous Rheumatoid Arthritis in the K/BxN Mouse Model by Decreasing Th1 and Th17 Cells in the Spleen, Lymph Nodes and Joint and Increasing T Regulatory Cells and IL-10 in the Joint.

Bonnie J B Lewis, Selena Cen, Ruqayyah J Almizraq, Beth Binnington, Rolf Spirig, Fabian Käsermann, Donald R Branch

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bonnie J B LewisDepartment of Laboratory Medicine and Pathobiology, University of Toronto, 30 Bond St., Toronto, ON M5B 1W8, Canada.
Selena CenCentre for Innovation, Canadian Blood Services, 30 Bond St., Toronto, ON M5B 1W8, Canada.
Ruqayyah J AlmizraqBluerock Therapeutics, 101 College St., Toronto, ON M5G 0A3, Canada.
Beth BinningtonCentre for Innovation, Canadian Blood Services, 30 Bond St., Toronto, ON M5B 1W8, Canada.
Rolf SpirigCSL Behring Biologics Research Center, 200031 Bern, Switzerland.
Fabian KäsermannCSL Behring Biologics Research Center, 200031 Bern, Switzerland.ORCID 0000-0002-4255-9350
Donald R BranchDepartment of Laboratory Medicine and Pathobiology, University of Toronto, 30 Bond St., Toronto, ON M5B 1W8, Canada.ORCID 0000-0002-8974-2451

Funding

Canadian Blood Services GFP award; Postdoc award
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

arthritishuman IgG1 rFc-µTP-L309Cinterleukin-1K/BxN micerecombinant Fc-hexamerTh17 cellsT-regulatory cells

Identifiers

PMID40648884
PMCPMC12250205

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.