ArticleNanomaterials (Basel, Switzerland)2025
Optimization of Solid Lipid Nanoparticle Formulation Using Design of Experiments, PART I:
Article in Nanomaterials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study presents a methodological framework for optimizing "blank" solid lipid nanoparticles (SLNs), focusing on the use of a design of experiments (DOE) approach. Rather than emphasizing the applications of SLNs, the objective is to identify and optimize critical formulation and process parameters-specifically those influencing particle size (PS), polydispersity index (PDI), and zeta potential (ZP)-during early development stages. A non-classical mixed design was applied using AZURAD
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