Evidence map›Paper›PMID 40648741›Full record

ArticleNanomaterials (Basel, Switzerland)2025

Optimization of Solid Lipid Nanoparticle Formulation Using Design of Experiments, PART I:

Margot Cassayre, Dany Teles de Souza, Magalie Claeys-Bruno, Alexandre Altié, Philippe Piccerelle, Christophe Sauzet

Abstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Margot CassayreCNRS, IRD, IMBE, Avignon Université, Aix-Marseille University, 13385 Marseille, France.ORCID 0000-0001-5755-5742
Dany Teles de SouzaCNRS, IRD, IMBE, Avignon Université, Aix-Marseille University, 13385 Marseille, France.
Magalie Claeys-BrunoCNRS, IRD, IMBE, Avignon Université, Aix-Marseille University, 13385 Marseille, France.ORCID 0000-0001-7168-2190
Alexandre AltiéCNRS, CINAM, Aix-Marseille University, 13009 Marseille, France.ORCID 0000-0003-0559-738X
Philippe PiccerelleCNRS, IRD, IMBE, Avignon Université, Aix-Marseille University, 13385 Marseille, France.
Christophe SauzetCNRS, IRD, IMBE, Avignon Université, Aix-Marseille University, 13385 Marseille, France.ORCID 0000-0002-6173-3051

Funding

Laboratoires Multaler (Yon-Ka Paris) (Argenteuil, France) 2019/0294Protisvalor (Aix-Marseille Université, France) REF PVM 2020-142
6 · The paper itself

Abstract

This study presents a methodological framework for optimizing "blank" solid lipid nanoparticles (SLNs), focusing on the use of a design of experiments (DOE) approach. Rather than emphasizing the applications of SLNs, the objective is to identify and optimize critical formulation and process parameters-specifically those influencing particle size (PS), polydispersity index (PDI), and zeta potential (ZP)-during early development stages. A non-classical mixed design was applied using AZURAD

Indexed as

design of experiments (DOE)formulationoptimizationphysical characterizationsolid lipid nanoparticle (SLN)statistics

Identifiers

PMID40648741
PMCPMC12250869

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.