Evidence map›Paper›PMID 40648343›Full record

ArticleSensors (Basel, Switzerland)2025

AuNP/Magnetic Bead-Enhanced Electrochemical Sensor Toward Dual Saliva Alzheimer's Biomarkers Detection.

Pengcheng Zhao, Jieyu Wang, Hongju Mao, Lin Zhou, Zhenhua Wu, Yunxing Lu, Teng Sun, Jianan Hui, Guowu Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sensors (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pengcheng ZhaoSchool of Stomatology, Dalian Medical University, Dalian 116000, China.
Jieyu WangSchool of Stomatology, Dalian Medical University, Dalian 116000, China.
Hongju MaoState Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
Lin ZhouState Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
Zhenhua WuState Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
Yunxing LuSchool of Science and Technology, Shanghai Open University, Shanghai 200433, China.
Teng SunLin Gang Laboratory, Shanghai 201306, China.
Jianan HuiState Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
Guowu MaSchool of Stomatology, Dalian Medical University, Dalian 116000, China.

Funding

National Key R&D Program of China 2023YFB3210300National Key R&D Program of China 2023YFB3210302National Natural Science Foundation of China 61971410National Natural Science Foundation of China 62171077National Natural Science Foundation of China 62231025National Natural Science Foundation of China 62271004National Natural Science Foundation of China 62271104Program of Science and Technology Commission of Shanghai Municipality 22ZR1473500Program of Science and Technology Commission of Shanghai Municipality 23141901100Program of Science and Technology Commission of Shanghai Municipality 24XTCX00700Science and Technology Program of Guangzhou 2024B03J0022
6 · The paper itself

Abstract

Alzheimer's disease (AD) early screening requires non-invasive, high-sensitivity detection of low-abundance biomarkers in complex biofluids like saliva. In this study, we present a miniaturized, silicon-based electrochemical sensor for sequential detection of two AD salivary biomarkers, lactoferrin (Lf) and amyloid β-protein 1-42 (Aβ

Indexed as

Alzheimer DiseaseBiosensing TechniquesElectrochemical TechniquesGoldMetal NanoparticlesSalivaAmyloid beta-PeptidesBiomarkersElectrodesHumansLactoferrinPeptide FragmentsAmyloid beta-Peptidesamyloid beta-protein (1-42)BiomarkersGoldLactoferrinPeptide FragmentsAlzheimer’s diseaseelectrochemical sensorgold nanoparticlesimmunomagnetic beads

Identifiers

PMID40648343
PMCPMC12252058

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.