Evidence map›Paper›PMID 40647882›Full record

ArticlePolymers2025

Bionic Bovine Achilles Tendon Collagen Composite Membrane Loaded with Anti-Inflammatory Kukoamine B Promotes Skin Wound Healing.

Ruting Luo, Yujie Mu, Le Zhao, Jinglin Hua, Lixin Cao, Danting Chen, Kun Li, Zhenkai Jin, Yanchuan Guo, Bing Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ruting LuoSchool of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 100048, China.
Yujie MuSchool of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 100048, China.
Le ZhaoSchool of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.ORCID 0000-0002-1213-1126
Jinglin HuaSchool of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 100048, China.
Lixin CaoSchool of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 100048, China.
Danting ChenSchool of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 100048, China.
Kun LiBTBU-YHZK Bioengineering Raw Material Development Laboratory, Beijing Technology and Business University, Beijing 102401, China.
Zhenkai JinBTBU-YHZK Bioengineering Raw Material Development Laboratory, Beijing Technology and Business University, Beijing 102401, China.
Yanchuan GuoTechnical Institute of Physics and Chemistry CAS, Beijing 100190, China.
Bing ZhangTechnical Institute of Physics and Chemistry CAS, Beijing 100190, China.
Min WangSchool of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 100048, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skin is the first line of defence between the human body and the outside world, and it is constantly exposed to external injuries and wounds for a variety of reasons. Collagen is a structural protein of the extracellular matrix and an important component of the dermis. As a wound dressing, collagen not only provides nutrients to wounds but also enhances the immune response in the pre-healing phase, making it an excellent biomaterial for healing. In this study, we used electrospinning and freeze-drying technology to prepare a Bovine Achilles Tendon Collagen (BATC) electrospun composite membrane and a BATC freeze-dried composite membrane using BATC as a substrate supplemented with 16.7% Polyethylene oxide (PEO) and 0.2% Kukoamine B (KuB). The physicochemical properties and biocompatibility of the BATC composite membrane were verified via scanning electron microscopy, Fourier-transform infrared spectroscopy, and DSC analysis and by measuring the DPPH radical-scavenging capacity, water absorption, water retention, in vitro drug release, and extract cytotoxicity. The BATC composite membrane was found to have a significant effect on skin wound healing, especially in the middle stage of healing, in a mouse full-thickness skin injury model. The BATC/PEO/KuB electrospun composite membrane (EBPK) had the best capacity for promoting wound healing and can be used as a wound dressing for in-depth research and development, and KuB, a monomer component with a clear structure and mechanism of action, can be used as a candidate component of composite dressings.

Indexed as

anti-inflammatoryBovine Achilles Tendon Collagendressingelectrospunwound healing

Identifiers

PMID40647882
PMCPMC12252409

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.