Design and Characterization of PAA/CHI/Triclosan Multilayer Films with Long-Term Antibacterial Activity.

Balzhan Savdenbekova, Aruzhan Sailau, Ayazhan Seidulayeva, Zhanar Bekissanova, Ardak Jumagaziyeva, Renata Nemkayeva

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Article in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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6 authors.

Balzhan SavdenbekovaFaculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan.ORCID 0000-0001-8812-5809

Aruzhan SailauFaculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan.ORCID 0000-0002-6174-5431

Ayazhan SeidulayevaFaculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan.

Zhanar BekissanovaFaculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan.ORCID 0000-0001-6142-0963

Ardak JumagaziyevaScientific Center for Anti-Infectious Drugs, Almaty 050060, Kazakhstan.

Renata NemkayevaNational Nanotechnology Laboratory of Open Type, Al-Farabi Kazakh National University, Almaty 050012, Kazakhstan.ORCID 0000-0002-8782-703X

Funding

Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan IRN AP19577150

6 · The paper itself

Abstract

The development of antibacterial coatings for biomedical applications is crucial to prevent implant-associated infections (IAIs). In this study, we designed and evaluated a multilayer coating based on chitosan (CHI), polyacrylic acid (PAA), and triclosan (TCS) using the layer-by-layer (LbL) self-assembly technique. The successful incorporation of TCS was confirmed by Fourier-transform infrared (FTIR) spectroscopy. Surface roughness and topography were analyzed using atomic force microscopy (AFM) and scanning electron microscopy (SEM). Additionally, the pH-dependent behavior of PAA/CHI films was studied to assess its effect on TCS loading. According to disk diffusion assays, coatings assembled at pH 5 (PAA5/CHI5/TCS) exhibited the strongest antibacterial activity, with inhibition zones of 60.0 ± 0.0 mm for

Indexed as

antibacterial coatingdrug deliverylayer-by-lavertriclosan

Identifiers

PMID40647799

DOI10.3390/polym17131789

PMCPMC12251587

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