Evidence map›Paper›PMID 40647530›Full record

ArticleCancers2025

Discordance Between Radiological and Pathological Responses to Pembrolizumab in Mismatch Repair-Deficient Metastatic Colorectal Cancer: Implications for Precision Oncology.

Yoshifumi Shimada, Mae Nakano, Akio Matsumoto, Hikaru Ozeki, Kaoru Abe, Yosuke Tajima, Daisuke Yamai, Hitoshi Nogami, Masato Nakano, Tatsuo Tani and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Yoshifumi ShimadaDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.ORCID 0000-0003-0524-236X
Mae NakanoDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.
Akio MatsumotoDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.
Hikaru OzekiDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.
Kaoru AbeDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.
Yosuke TajimaDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.ORCID 0000-0002-1044-8066
Daisuke YamaiDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.
Hitoshi NogamiDepartment of Gastrointestinal Surgery, Niigata Cancer Center Hospital, Niigata 951-8133, Japan.
Masato NakanoDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.ORCID 0000-0002-1475-7405
Tatsuo TaniDepartment of Surgery, Nagaoka Red Cross Hospital, Nagaoka 940-2085, Japan.
Mikako KawaharaDepartment of Surgery, Nagaoka Chuo General Hospital, Nagaoka 940-8653, Japan.
Atsushi NishimuraDepartment of Surgery, Nagaoka Chuo General Hospital, Nagaoka 940-8653, Japan.ORCID 0000-0002-9310-345X
Yuka KobayashiDepartment of Oncology, Nagaoka Chuo General Hospital, Nagaoka 940-8653, Japan.
Yuta BambaDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.
Susumu SuzukiDepartment of Surgery, Niigata Prefectural Central Hospital, Joetsu 943-0192, Japan.
Hidehito OyanagiDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.
Taku OhashiDepartment of Surgery, Niigata Prefectural Shibata Hospital, Shibata 957-8588, Japan.
Hitoshi KameyamaDepartment of Digestive Surgery, Niigata City General Hospital, Niigata 950-1197, Japan.
Akira IwayaDepartment of Digestive Surgery, Niigata City General Hospital, Niigata 950-1197, Japan.
Hiroshi IchikawaDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.ORCID 0000-0002-6515-5316
Jun SakataDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.
Toshifumi WakaiDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.ORCID 0000-0003-2443-3428

Funding

This work was supported by JSPS KAKENHI Grant Number JP25K11923 Grant Number JP25K11923
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

clinical complete responsecolorectal cancerdiscordancemicrosatellite instability-highmismatch repair deficientpathological complete responsepathological responsepembrolizumabradiological response

Identifiers

PMID40647530
PMCPMC12248757

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.