Evidence map›Paper›PMID 40647512›Full record

ArticleCancers2025

Correlations Between Mammographic Breast Density and Outcomes After Neoadjuvant Chemotherapy in Patients with Locally Advanced Breast Cancer.

Veenoo Agarwal, Lisa Spalding, Hilary Martin, Ellie Darcey, Jennifer Stone, Andrew Redfern

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Veenoo AgarwalFiona Stanley Hospital, Murdoch, WA 6150, Australia.ORCID 0000-0003-3951-2946
Lisa SpaldingHarry Perkins Institute of Medical Research, Robin Warren Drive, Murdoch, WA 6150, Australia.ORCID 0000-0002-3885-9625
Hilary MartinFiona Stanley Hospital, Murdoch, WA 6150, Australia.
Ellie DarceySchool of Medicine, The University of Western Australia, Crawley, WA 6009, Australia.
Jennifer StoneSchool of Medicine, The University of Western Australia, Crawley, WA 6009, Australia.ORCID 0000-0001-5077-0124
Andrew RedfernFiona Stanley Hospital, Murdoch, WA 6150, Australia.ORCID 0000-0001-6728-8713

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAn inverse association between high mammographic breast density (MBD) and pathologic complete response (pCR) following neoadjuvant chemotherapy (NAC) for early breast cancer (EBC) has been reported. However, the relationship of MBD to relapse-free (RFS) and breast cancer-specific survival (BCSS) is unexplored. This study aims to validate the relationship between MBD and NAC pCR in EBC and to assess correlations with RFS and BCSS. MATERIALS &

methodsMBD was measured on contralateral mammograms in 127 women before NAC using Cumulus software. The percent dense area was correlated with patient and tumour characteristics, pCR, RFS and BCSS.

resultsMean MBD was higher in relapsing patients (

conclusionsObesity and high MBD may interact to cause chemoresistance. Further research in these patients is warranted.

Indexed as

breast cancermammographic densitypathological response

Identifiers

PMID40647512
PMCPMC12249418

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.