Evidence map›Paper›PMID 40647509›Full record

ArticleCancers2025

Multivariate Framework of Metabolism in Advanced Prostate Cancer Using Whole Abdominal and Pelvic Hyperpolarized

Hsin-Yu Chen, Ivan de Kouchkovsky, Robert A Bok, Michael A Ohliger, Zhen J Wang, Daniel Gebrezgiabhier, Tanner Nickles, Lucas Carvajal, Jeremy W Gordon, Peder E Z Larson and 3 more

Erratum issuedAbstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Proof-of-Concept Study of Hyperpolarized [1-Radiology. Imaging cancer · 2026
    Article
  2. Review
  3. Use of Nuclear Magnetic Resonance (NMR) to Study Cancer Metabolism.Advances in experimental medicine and biology · 2026
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Hsin-Yu ChenDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-2765-1685
Ivan de KouchkovskyHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158, USA.
Robert A BokDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA.ORCID 0000-0003-1737-9056
Michael A OhligerDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA.ORCID 0000-0001-6878-8189
Zhen J WangDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA.
Daniel GebrezgiabhierDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-8118-3931
Tanner NicklesDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA.
Lucas CarvajalDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA.
Jeremy W GordonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA.
Peder E Z LarsonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA.ORCID 0000-0003-4183-3634
John KurhanewiczDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-3544-5339
Rahul AggarwalHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158, USA.
Daniel B VigneronDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA.

Funding

TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUAN XU · 2011 to 2026
$19.9M
Supplement for Development and Translation of Specialized Hyperpolarized C-13 MRI Methods for Alzheimer's DiseaseU01EB026412 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORDON, JEREMY WILLIAM, VIGNERON, DANIEL B · 2019 to 2023
$6.6M
Measuring Metabolic Activity in Prostate Cancer Bone Metastases Using Hyperpolarized 13C Pyruvate MRI for Improved Targeted Therapy MonitoringR01CA256740 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AGGARWAL, RAHUL, VIGNERON, DANIEL B · 2021 to 2025
$3.3M
Hyperpolarized C-13 MRI Techniques to Monitor Radiation Therapy Response in Prostate Cancer PatientsR01CA238379 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOK, ROBERT A, VIGNERON, DANIEL B · 2021 to 2025
$3.3M
Targeting Neuroendocrine Prostate Cancer Using Multi-Probe Hyperpolarized 13C MRI for Improved Treatment and Therapeutic MonitoringR01CA215694 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AGGARWAL, RAHUL, KURHANEWICZ, JOHN · 2017 to 2021
$3.3M
Upgrade of an Obsolete 3.35T DNP Polarizer to enable new HP C-13 Technology DevelopmentS10OD025077 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VIGNERON, DANIEL B · 2020 to 2020
$1.7M
NCI NIH HHS R01 CA215694NCI NIH HHS R01 CA238379NCI NIH HHS R01 CA256740NIBIB NIH HHS P41 EB013598NIBIB NIH HHS U01 EB026412NIH HHS 1 S10 OD025077-01A1NIH HHS 5P41EB013598-14A99NIH HHS 5R01CA215694-05A99NIH HHS 5R01CA238379-04A99NIH HHS 5R01CA256740-05A99NIH HHS 5U01EB026412-05A99NIH HHS S10 OD025077
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

advanced prostate cancerhyperpolarized 13C MRIimaging featuresmetabolismoverall survivalpyruvate

Identifiers

PMID40647509
PMCPMC12248915

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.