ArticleCancers2025
Immunosuppressive Tumor Microenvironment of Osteosarcoma.
Abstract read
In one paragraph
Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Single-cell sequencing profiling of intratumoral heterogeneity and immunosuppressive microenvironment in primary thyroid cancer and lymph node metastases.Oncoimmunology · 2026Article
- The evolution of cellular therapies in sarcoma: Breakthroughs, challenges, and future directions.Human vaccines & immunotherapeutics · 2026Review
- Bone niche-driven antitumor immune failure in osteosarcoma: Mechanisms and therapeutic implications (Review).Oncology letters · 2026Review
- Osteosarcoma Across the Age Spectrum: Why Outcomes Diverge and Trials Must Adapt.Journal of clinical medicine · 2026Review
- miR-424-5p Regulates Stem-like and Malignant Phenotypes in Osteosarcoma by Targeting FZD4.Cancers · 2026Article
- Integrative machine learning and multi-omics identify a centromere gene signature and validate B3GALT4 as a tumor suppressor in osteosarcoma.Journal of bone oncology · 2026Article
- Extracellular vesicles in osteosarcoma: bridging resistance, immunity, and clinical translation.Journal of bone oncology · 2026Review
- Integrated Bulk and Single-Cell Transcriptomics Reveals the C3-C3AR1 Axis as a Candidate Mediator of Coagulome-Immune Crosstalk in Osteosarcoma.Biomedicines · 2026Article
- Selenium-Loaded Calcium Phosphate with Long-Term and Curative Dosage Drug Release for Post-Surgical Osteosarcoma Management and Osteogenesis.International journal of molecular sciences · 2026Article
- <p>Tumor microenvironment in bone sarcomas: Implications for immunotherapy and emerging therapeutic vulnerabilities (Review)</p>.Oncology reports · 2026Review
- Metabolic-immune crosstalk in osteosarcoma: mechanisms and therapeutic opportunities.Frontiers in immunology · 2026Review
- Re-Arming the Immunological Radar: The Translational Landscape of Dendritic Cell-Centric Nanotherapeutics and Microenvironment Remodeling for Osteosarcoma.International journal of nanomedicine · 2026Review
- Advances in the association between tumor immune microenvironment remodeling in osteosarcoma and the risk of pathological fractures.Frontiers in genetics · 2026Review
- SLC7A7 Downregulation in Monocytes Drives Immunosuppression and Osteosarcoma Progression.International journal of genomics · 2026Article
- Nutritional biomarkers regulating tumor immune microenvironment in osteosarcoma and as predictors of immune checkpoint inhibitor responses.Frontiers in immunology · 2026Review
- Immune reprogramming in the bone marrow microenvironment: a new perspective on the bone immune microenvironment of postmenopausal osteoporosis.Frontiers in immunology · 2026Review
- Immune exclusion as a recurrent immune-escape state driving treatment resistance in osteosarcoma: insights from single-cell, spatial, and multi-omics studies.Frontiers in immunology · 2026Review
- Clinical and tissue evidence of immune dysregulation in osteosarcoma: altered peripheral neutrophil-related indices and reduced APOE expression.Frontiers in immunology · 2026Article
- The synergistic role of ferroptosis in osteosarcoma immunotherapy.Medical oncology (Northwood, London, England) · 2025Review
- Targeting the osteosarcoma immune microenvironment for improved immunotherapy and translational applications.Discover oncology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors.
Aaron Michael TaylorThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.ORCID 0000-0002-2544-5888
Jianting ShengSystems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston, TX 77030, USA.
Patrick Kwok Shing NgThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
Jeffrey M HarderThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
Parveen KumarThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.ORCID 0000-0003-2739-273X
Ju Young AhnSystems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston, TX 77030, USA.ORCID 0000-0002-0946-4157
Yuliang CaoSystems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston, TX 77030, USA.
Alissa M DzisThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
Nathaniel L JilletteThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
Andrew GoodspeedUniversity of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0001-7055-7128
Avery BodlakUniversity of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Qian WuUniversity of Connecticut School of Medicine, Farmington, CT 06032, USA.
Michael S IsakoffUniversity of Connecticut School of Medicine, Farmington, CT 06032, USA.ORCID 0000-0003-4790-9919
Joshy GeorgeThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.ORCID 0000-0001-8510-8229
Jessica D S GrassmannThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.ORCID 0000-0001-9076-452X
Diane LuoThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
William F FlynnThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
Elise T CourtoisThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.ORCID 0000-0002-8749-2719
Paul RobsonThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
Masanori HayashiUniversity of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-9508-0159
Alini Trujillo PaolilloHospital do GRAACC, São Paulo 04039-001, Brazil.ORCID 0000-0001-6609-196X
Antonio Sergio PetrilliHospital do GRAACC, São Paulo 04039-001, Brazil.
Silvia Regina Caminada de ToledoHospital do GRAACC, São Paulo 04039-001, Brazil.
Fabiola Sara BalarezoHartford Hospital, Hartford, CT 06106, USA.
Adam D LindsayHartford Hospital, Hartford, CT 06106, USA.
Bang HoangMontefiore Medical Center, Bronx, NY 10467, USA.
Stephen T C WongSystems Medicine and Bioengineering Department, Houston Methodist Neal Cancer Center, Houston, TX 77030, USA.ORCID 0000-0001-9188-6502
Ching C LauThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
Funding
Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI Paul Robson · 1985 to 2026
$61.9MSpatiotemporal modeling of cancer-niche interactions in breast cancer bone metastasisU01CA253553 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI WONG, STEPHEN TC, ZHANG, XIANG · 2020 to 2024
$3.0MCapoStrong Fund NAFAPESP 19/18670-9Flow Cytometry shared resources RRID:SCR_022035John S Dunn Research Foundation NANational Pediatric Cancer Foundation NANCI NIH HHS P30 CA034196NIH HHS P30 CA06934NIH HHS U01CA253553St. Baldrick's Foundation Scholar Award NAStrawbridge Cancer Therapeutic Fund NAThe Jackson Laboratory CATch Program NAT. T. & W.F. Chao Foundation NAUniversity of Colorado Bioinformatics and Biostatistics Shared Resource RRID:SCR_021984
Abstract
PubMed holds no abstract for this paper.
Indexed as
immune microenvironmentosteosarcomasingle-cell sequencingspatial transcriptomics
Identifiers
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.