Evidence map›Paper›PMID 40647382›Full record

ReviewCancers2025

Supraclavicular Lymph Node Dissection in Breast Cancer with Synchronous Supraclavicular Metastases: A Systematic Review and Network Meta-Analysis.

George Shiyao He, Jolene Li Ling Chia, Emmeline Elaine Cua-De Los Santos, Wong Hung Chew, Wee Yao Koh, Qin Xiang Ng, Samuel Ow, Serene Si Ning Goh

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

George Shiyao HeNUS Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore.ORCID 0000-0002-1090-8819
Jolene Li Ling ChiaNUS Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore.
Emmeline Elaine Cua-De Los SantosDepartment of Surgery, National University Hospital, Singapore 119074, Singapore.
Wong Hung ChewNUS Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore.
Wee Yao KohDepartment of Radiation Oncology, National University Hospital, Singapore 119074, Singapore.
Qin Xiang NgSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 119228, Singapore.ORCID 0000-0001-8561-2513
Samuel OwDepartment of Haematology-Oncology, National University Cancer Institute, Singapore 119074, Singapore.ORCID 0000-0002-2229-7971
Serene Si Ning GohNUS Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore.ORCID 0000-0003-4916-2142

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesSynchronous ipsilateral supraclavicular lymph node metastases (sISLMs) in breast cancer are rare and associated with poor prognosis. The optimal locoregional treatment strategy remains unclear, particularly regarding the role of supraclavicular lymph node dissection (SLND).

methodsWe conducted a systematic review and network meta-analysis, including studies published up to end December 2023, to compare the outcomes of SLND combined with radiotherapy (RT) and systemic therapy (ST), SLND with ST alone, and ST alone, using RT + ST as the reference.

resultsTen studies involving 3346 patients were included for overall survival (OS) analysis, and six studies were included for disease-free survival (DFS). SLND + RT + ST showed similar OS and DFS compared to RT + ST. Sensitivity analyses revealed that SLND limited to level V improved OS (HR: 0.47, 95% CI: 0.29-0.77), while more extensive dissections (level V+) worsened outcomes (HR: 1.41, 95% CI: 1.10-1.80).

conclusionsThese findings suggest that selective SLND may benefit certain patients, but broader application should be approached with caution pending results from future randomized trials.

Indexed as

breast cancerdisease-free survivallocoregional therapynetwork meta-analysisoverall survivalsupraclavicular lymph node dissectionsupraclavicular lymph node metastases

Identifiers

PMID40647382
PMCPMC12248947

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.