Evidence map›Paper›PMID 40647370›Full record

ArticleCancers2025

Elucidating the Role of

Marta Rada Rodríguez, Bárbara Angulo Biedma, Irene Rodríguez Pérez, Javier Azúa Romeo

Abstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Patterns ofJournal of gastrointestinal oncology · 2026
    Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Marta Rada RodríguezDepartment of Human Anatomy and Histology, Universidad de Zaragoza, Calle Pedro Cerbuna, 50009 Zaragoza, Spain.
Bárbara Angulo BiedmaArea of Molecular Biology, Analiza, 28008 Madrid, Spain.
Irene Rodríguez PérezArea of Pathology, Analiza, 28008 Madrid, Spain.
Javier Azúa RomeoChief of Pathology, Analiza, 28008 Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

methodsWe retrospectively and cross-sectionally reviewed the cases of 648 patients with a histological diagnosis of colon adenocarcinoma. Of these, 166 had partial molecular studies, and 42 cases were selected based on the availability of the genetic markers targeted in this study. We analyzed the frequency of mutations in these genes, as well as their correlation with microsatellite instability (MSI).

resultsA high mutation rate was found in the

conclusionsComprehensive NGS profiling from the start improves diagnostic efficiency by saving time, tissue, and costs compared to gene-by-gene analysis. It also enables better molecular characterization and facilitates tailored therapeutic strategies, particularly in identifying candidates for targeted therapy and immunotherapy. This approach supports efficient tumor classification based on using

Indexed as

biomarkerBRAFDNA mismatch repairgenetic mutationsKRASmicrosatellite instabilitymolecular profilingnext-generation sequencingNRASprecision oncologysporadic colorectal cancer

Identifiers

PMID40647370
PMCPMC12248870

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.