Evidence map›Paper›PMID 40647369›Full record

ArticleCancers2025

Association of Percutaneous Endoscopic Gastrostomy (PEG) Tube Placement with Unplanned Hospitalization for Head and Neck Cancer.

Sung Jun Ma, Jas Virk, Tyler V Schrand, Jasmin Gill, Neil Almeida, Harshini K Cheruvu, Vishal Gupta, Kimberly E Wooten, Moni A Kuriakose, Michael R Markiewicz and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sung Jun MaDepartment of Radiation Oncology, The Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, 460 W 10th Ave, Columbus, OH 43210, USA.
Jas VirkJacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, 955 Main Street, Buffalo, NY 14203, USA.ORCID 0000-0001-9938-6991
Tyler V SchrandDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, 665 Elm Street, Buffalo, NY 14203, USA.ORCID 0009-0007-7283-4951
Jasmin GillUniversity at Buffalo, The State University of New York, 12 Capen Hall, Buffalo, NY 14260, USA.
Neil AlmeidaDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, 665 Elm Street, Buffalo, NY 14203, USA.
Harshini K CheruvuDepartment of Statistics & Data Science, Cornell University, 1198 Comstock Hall, Ithaca, NY 14853, USA.
Vishal GuptaDepartment of Head & Neck/Plastic & Reconstructive Surgery, Roswell Park Comprehensive Cancer Center, 665 Elm Street, Buffalo, NY 14203, USA.ORCID 0000-0001-5630-6672
Kimberly E WootenDepartment of Head & Neck/Plastic & Reconstructive Surgery, Roswell Park Comprehensive Cancer Center, 665 Elm Street, Buffalo, NY 14203, USA.
Moni A KuriakoseDepartment of Head & Neck/Plastic & Reconstructive Surgery, Roswell Park Comprehensive Cancer Center, 665 Elm Street, Buffalo, NY 14203, USA.
Michael R MarkiewiczDepartment of Head & Neck/Plastic & Reconstructive Surgery, Roswell Park Comprehensive Cancer Center, 665 Elm Street, Buffalo, NY 14203, USA.
Ryan P McSpaddenDepartment of Head & Neck/Plastic & Reconstructive Surgery, Roswell Park Comprehensive Cancer Center, 665 Elm Street, Buffalo, NY 14203, USA.
Wesley L HicksDepartment of Head & Neck/Plastic & Reconstructive Surgery, Roswell Park Comprehensive Cancer Center, 665 Elm Street, Buffalo, NY 14203, USA.
Mark K FarrugiaDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, 665 Elm Street, Buffalo, NY 14203, USA.ORCID 0000-0002-0261-0334
Anurag K SinghDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, 665 Elm Street, Buffalo, NY 14203, USA.

Funding

National Cancer Institute Cancer Center Support Grant P30CA016056
6 · The paper itself

Abstract

BACKGROUND/

objectivesThere is a varying need for nutritional support among head and neck cancer (HNC) patients. Unplanned hospitalization is frequent with definitive chemoradiation. However, the association of unplanned hospitalizations with cancer control outcomes and percutaneous endoscopic gastrostomy (PEG) tube placement is not well-understood. This study aims to evaluate the clinical outcomes stratified by unplanned hospitalizations and to identify the prognostic factors associated with unplanned hospitalizations.

methodsThis retrospective cohort study included 657 HNC patients treated with definitive chemoradiation at a single institution between 2007 and 2023. Relevant clinical data were evaluated for unplanned hospitalizations, prophylactic vs. therapeutic PEG tube placement, and clinical outcomes. Multivariable, subgroup, and matched-pair analyses were performed to account for potential confounding variables. The main outcomes and measures used are overall survival (OS), progression-free survival (PFS), locoregional failure (LRF), distant failure (DF), and incidence of unplanned hospitalization.

resultsUnplanned hospitalizations occurred in 190 (29%) patients, which were associated with worse OS (adjusted hazards ratio [aHR] of 2.07, 95% confidence interval [CI] of 1.53-2.81,

conclusionsUnplanned hospitalization was an independent, adverse prognostic factor for poor survival, but not oncologic outcomes. Unplanned hospitalization incidence was largely driven by those who required a therapeutic PEG tube, while it was the lowest for those who never needed a PEG tube.

Indexed as

concurrent chemoradiationdysphagiahead and neck cancerodynophagiapercutaneous endoscopic gastrostomy

Identifiers

PMID40647369
PMCPMC12249407

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.