Evidence map›Paper›PMID 40647347›Full record

ArticleNutrients2025

Diet Diversity and Adherence to a Mediterranean Diet Pattern in Pregnancy Is Protective Against the Development of Early-Childhood Atopic Dermatitis.

Kristina Nadine Heye, Leonie Helen Bogl, Mari Sasaki, Remo Frei, Anna Breunig, Neeta Bühler, Christian Raphael Kahlert, Mehmet Goekkaya, Claudia Traidl-Hoffmann, Roger Lauener and 2 more

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In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kristina Nadine HeyeDivision of Pneumology and Allergology, Children's Hospital of Eastern Switzerland, 9006 St. Gallen, Switzerland.ORCID 0000-0003-3578-9200
Leonie Helen BoglDepartment Nutrition and Dietetics, Faculty of Health Professions, Bern University of Applied Sciences, 3008 Bern, Switzerland.ORCID 0000-0003-4316-2619
Mari SasakiDivision of Respiratory Medicine and Allergology, Department of Pediatrics, Inselspital, University of Bern, 3010 Bern, Switzerland.
Remo FreiDivision of Respiratory Medicine and Allergology, Department of Pediatrics, Inselspital, University of Bern, 3010 Bern, Switzerland.ORCID 0009-0007-3481-8192
Anna BreunigDivision of Pneumology and Allergology, Children's Hospital of Eastern Switzerland, 9006 St. Gallen, Switzerland.
Neeta BühlerDivision of Pneumology and Allergology, Children's Hospital of Eastern Switzerland, 9006 St. Gallen, Switzerland.
Christian Raphael KahlertDivision of Pneumology and Allergology, Children's Hospital of Eastern Switzerland, 9006 St. Gallen, Switzerland.ORCID 0000-0002-0784-3276
Mehmet GoekkayaInstitute of Environmental Medicine, Helmholtz Munich-German Research Center for Environmental Health, 86156 Augsburg, Germany.ORCID 0000-0002-9924-9564
Claudia Traidl-HoffmannChristine Kühne-Center for Allergy Research and Education (CK-CARE), 7265 Davos, Switzerland.
Roger LauenerDivision of Pneumology and Allergology, Children's Hospital of Eastern Switzerland, 9006 St. Gallen, Switzerland.
Ck-Care Study Group
Caroline RoduitDivision of Pneumology and Allergology, Children's Hospital of Eastern Switzerland, 9006 St. Gallen, Switzerland.ORCID 0000-0002-5988-0570

Funding

Christine Kühne - Center for Allergy Research and Education (CK-CARE) CARE study (no specific grant number)
6 · The paper itself

Abstract

BACKGROUND/

objectivesThe role of maternal diet in atopic dermatitis (AD) requires better understanding, as AD often manifests early in life and precedes other allergic diseases. We evaluated the association between maternal diet and AD up to 2 years of age.

methodsA total of 116 mother-child dyads from the CARE birth cohort study were included. Maternal diet during pregnancy was assessed with a validated self-administered 97-item food frequency questionnaire, and dietary scores were calculated. AD was evaluated at ages 4 months, 1 year, and 2 years. The associations between maternal dietary patterns and AD were examined by logistic regression analysis adjusting for total energy intake, gender of the child, maternal antibiotic therapy during pregnancy, and history of atopic disease among both parents.

resultsOf the 116 children, 27 (23.3%) developed AD by 2 years, 11 of whom (40.7%) had persistent AD within the first 2 years. AD risk was reduced with a higher Mediterranean diet score during pregnancy (upper median > 3 points versus lower median: adjusted OR 0.24, 95% CI 0.08-0.69,

conclusionsAdherence to a Mediterranean diet and a diverse diet during pregnancy may decrease the risk of developing early childhood AD. This highlights the synergistic role of nutrients in dietary patterns as they modulate immune development and disease susceptibility.

Indexed as

Dermatitis, AtopicDiet, MediterraneanMaternal Nutritional Physiological PhenomenaPatient ComplianceAdultChild, PreschoolCohort StudiesFemaleHumansInfantMalePregnancyatopic dermatitisfood diversityfood frequency questionnairematernal dietMediterranean dietpregnancy

Identifiers

PMID40647347
PMCPMC12252201

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.