Evidence map›Paper›PMID 40647197›Full record

Trial reportNutrients2025

Effect of Almond Milk Versus Cow Milk on Postprandial Glycemia, Lipidemia, and Gastrointestinal Hormones in Patients with Overweight or Obesity and Type 2 Diabetes: A Randomized Controlled Clinical Trial.

Shilton Dhaver, Marwa Al-Badri, Joanna Mitri, Abd Almasih Barbar Askar, Adham Mottalib, Osama Hamdy

Abstract readRandomized Controlled TrialComparative Study
In one paragraph

Trial report in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shilton DhaverClinical, Behavioral & Outcomes Research, Joslin Diabetes Center, Boston, MA 02215, USA.ORCID 0000-0002-5281-6728
Marwa Al-BadriClinical, Behavioral & Outcomes Research, Joslin Diabetes Center, Boston, MA 02215, USA.ORCID 0000-0002-4998-9708
Joanna MitriClinical, Behavioral & Outcomes Research, Joslin Diabetes Center, Boston, MA 02215, USA.
Abd Almasih Barbar AskarClinical, Behavioral & Outcomes Research, Joslin Diabetes Center, Boston, MA 02215, USA.ORCID 0009-0008-7846-6667
Adham MottalibClinical, Behavioral & Outcomes Research, Joslin Diabetes Center, Boston, MA 02215, USA.
Osama HamdyClinical, Behavioral & Outcomes Research, Joslin Diabetes Center, Boston, MA 02215, USA.

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI JEAN E. SCHAFFER · 1986 to 2026
$50.5M
National Dairy Council N/ANIDDK NIH HHS P30 DK036836
6 · The paper itself

Abstract

backgroundAlmond milk is often seen as a healthier alternative to cow milk. However, its effect on postprandial glycemia compared to 2% milk is unclear. Here, we compared the postprandial glycemic effect of almond milk versus carbohydrate- or caloric-matched 2% milk, each served with oatmeal to patients with type 2 diabetes (T2D).

methodsIn this crossover, three-way, open-label study, 22 participants (mean age 66 ± 7.4 years, 36% female), with T2D and overweight or obesity, consumed oatmeal served with almond milk (ALM), carbohydrate-matched 2% milk (MLKCRB), or calorie-matched 2% milk (MLKCAL) on separate days and in a random order. The primary outcome was glucose incremental area under the curve for 240 min (iAUC0-240). The secondary outcomes included postprandial serum insulin, glucagon, plasma free fatty acids (FFAs), serum triglycerides, leptin, and gastrointestinal hormones (PYY, active GLP-1, GIP, amylin, cholecystokinin, and ghrelin).

resultsWe did not find any difference in either the primary endpoint or secondary endpoints between the three groups. However, iAUC0-240 for insulin and glucagon was significantly higher in MLKCRB vs. ALM (FDR = 0.002 and 0.02, respectively).

conclusionsAlmond milk does not offer any additional glycemic benefit over 2% milk and does not differ in its postprandial effects on FFAs, serum triglycerides, leptin, and gastrointestinal hormones over 4 h. Nonetheless, carbohydrate-matched 2% milk elicited greater insulin and glucagon response compared to almond milk, warranting further investigation into its long-term implications.

Indexed as

Blood GlucoseDiabetes Mellitus, Type 2Gastrointestinal HormonesLipidsMilkObesityPrunus dulcisAgedAnimalsCattleCross-Over StudiesFemaleHumansInsulinMaleMiddle AgedBlood GlucoseGastrointestinal HormonesInsulinLipidsalmond milkdairyfree fatty acidsobesitytype 2 diabetes

Identifiers

PMID40647197
PMCPMC12251527

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.