ArticleNutrients2025
Timing of Dietary Fatty Acids to Optimize Reduced Risk of Type 2 Diabetes Mellitus: Findings from China Health and Nutrition Survey.
Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
objectivesChrononutrition highlights the significance of temporal consumption behavior for a healthy dietary pattern. This study investigated the relationship between dietary fatty acid (FA) intake timing and type 2 diabetes mellitus (T2DM) risk.
methodsA total of 14,518 participants in the China Health and Nutrition Survey (1991-2015) were recruited. Dietary intake and mealtime were collected via three consecutive 24 h dietary recalls. Multivariable Cox proportional hazard models were employed to estimate the association between FA intake at meals and T2DM risk. Differences in FA intake between dinner and breakfast (Δ = dinner-breakfast) were calculated for each type of FA intake. Sensitivity analyses considering the effects of snacks, the sum of different types of FAs, and other confounding factors were performed. The isocaloric substitution model was used to view the risk changes according to the shifted mealtime.
resultsDuring an average of 10.1-year follow-up, 1048 T2DM cases occurred. T2DM risk was inversely associated with n-3 polyunsaturated FAs (n-3 PUFAs) (
conclusionsTimely consumption of dietary FAs, particularly n-3 PUFAs and plant-based MUFAs at dinner versus breakfast, is crucial for T2DM prevention.
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