Evidence map›Paper›PMID 40647181›Full record

Trial reportNutrients2025

A Secondary Analysis of Caloric Restriction and Exercise Effects on Cognitive Function in Functionally Limited Postmenopausal Women with Overweight or Obesity.

Christian W McLaren, Rebecca L Pearl, Glenn E Smith, Stephen D Anton

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Christian W McLarenDepartment of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32611, USA.ORCID 0000-0001-5997-3868
Rebecca L PearlDepartment of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32611, USA.
Glenn E SmithDepartment of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32611, USA.
Stephen D AntonDepartment of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32611, USA.ORCID 0000-0001-5020-5280

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Stephen D Anton · 2007 to 2026
$22.8M
Research Training in Non-Pharmacological Interventions for Cognition in Aging, MCI, and Alzheimer's DiseaseT32AG020499 · NIA · UNIVERSITY OF FLORIDA · PI MARSISKE, MICHAEL, SMITH, GLENN E. · 2003 to 2024
$3.7M
National Institute of Health-Funded Claude D Pepper Older Americans Independence Center P30-AG028740NIA NIH HHS P30 AG028740NIA NIH HHS T32 AG020499The National Institute on Aging - Training Grant T32-AG020499
6 · The paper itself

Abstract

backgroundPostmenopausal women face a higher risk of obesity and related chronic diseases. While lifestyle interventions improve cardiometabolic health and physical function, their effects on cognitive function remain understudied, especially in diverse populations. This study examined the impact of a lifestyle intervention combining caloric restriction and exercise on cognitive function in a diverse sample of postmenopausal women with overweight or obesity and functional limitations.

methodsThis study represents a secondary analysis of a previously conducted pilot trial, in which 34 participants were randomly assigned to a 24-week intervention: (i) caloric restriction plus exercise (CR + E; n = 17) or (ii) educational control (EC; n = 17). In the CR + E group, participants engaged in group-based weight management focused on caloric restriction and three weekly exercise sessions, including walking and lower-body resistance training. The EC group attended monthly health education lectures. Changes in cognitive scores were assessed using the Digit Symbol Substitution Test (DSST) and the Controlled Oral Word Association (COWA) test. Additionally, we explored the correlation between changes in cognitive scores and physical function in the CR + E group.

resultsIn the CR + E group, DSST scores significantly improved compared to the EC group (

conclusionsThe preliminary results of this study suggest that CR + E may improve complex attention in functionally limited postmenopausal women with overweight or obesity but does not appear to significantly affect verbal fluency.

Indexed as

Caloric RestrictionCognitionExerciseExercise TherapyObesityOverweightPostmenopauseAgedFemaleHumansMiddle AgedPilot Projectscalorie restrictioncognitionexerciselifestyleobesitypostmenopausalrandomized controlled trialwomen

Identifiers

PMID40647181
PMCPMC12251159

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.