Evidence map›Paper›PMID 40646923›Full record

ArticleFoods (Basel, Switzerland)2025

Screening and Relative Quantification of Migration from Novel Thermoplastic Starch and PBAT Blend Packaging.

Phanwipa Wongphan, Elena Canellas, Cristina Nerín, Carlos Estremera, Nathdanai Harnkarnsujarit, Paula Vera

Abstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Phanwipa WongphanDepartment of Packaging and Materials Technology, Faculty of Agro-Industry, Kasetsart University, 50 Ngam Wong Wan Rd., Latyao, Chatuchak, Bangkok 10900, Thailand.ORCID 0000-0003-4702-3384
Elena CanellasGUIA Group, Department of Analytical Chemistry, University of Zaragoza, I3A, María de Luna, 3, 50018 Zaragoza, Spain.
Cristina NerínGUIA Group, Department of Analytical Chemistry, University of Zaragoza, I3A, María de Luna, 3, 50018 Zaragoza, Spain.ORCID 0000-0003-2685-5739
Carlos EstremeraGUIA Group, Department of Analytical Chemistry, University of Zaragoza, I3A, María de Luna, 3, 50018 Zaragoza, Spain.
Nathdanai HarnkarnsujaritDepartment of Packaging and Materials Technology, Faculty of Agro-Industry, Kasetsart University, 50 Ngam Wong Wan Rd., Latyao, Chatuchak, Bangkok 10900, Thailand.ORCID 0000-0001-6555-1637
Paula VeraGUIA Group, Department of Analytical Chemistry, University of Zaragoza, I3A, María de Luna, 3, 50018 Zaragoza, Spain.

Funding

National Research Council of Thailand (NRCT), Contract No. N41A640190 (The Royal Golden Jubilee Ph.D. Program). National Research Council of Thailand (NRCT), Contract No. N41A640190 (The Royal Golden Jubilee Ph.D. Program).
6 · The paper itself

Abstract

A novel biodegradable food packaging material based on cassava thermoplastic starch (TPS) and polybutylene adipate terephthalate (PBAT) blends containing food preservatives was successfully developed using blown-film extrusion. This active packaging is designed to enhance the appearance, taste, and color of food products, while delaying quality deterioration. However, the incorporation of food preservatives directly influences consumer perception, as well as health and safety concerns. Therefore, this research aims to assess the risks associated with both intentionally added substances (IAS) and non-intentionally added substances (NIAS) present in the developed active packaging. The migration of both intentionally and non-intentionally added substances (IAS and NIAS) was evaluated using gas chromatography-mass spectrometry (GC-MS) and ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS). Fifteen different volatile compounds were detected, with the primary compound identified as 1,6-dioxacyclododecane-7,12-dione, originating from the PBAT component. This compound, along with others, resulted from the polymerization of adipic acid, terephthalic acid, and butanediol, forming linear and cyclic PBAT oligomers. Migration experiments were conducted using three food simulants-95% ethanol, 10% ethanol, and 3% acetic acid-over a period of 10 days at 60 °C. No migration above the detection limits of the analytical methods was observed for 3% acetic acid and 10% ethanol. However, migration studies with 95% ethanol revealed the presence of new compounds formed through interactions between the simulant and PBAT monomers or oligomers, indicating the packaging's sensitivity to high-polarity food simulants. Nevertheless, the levels of these migrated compounds remained below the regulatory migration limits.

Indexed as

biodegradablefood packagingmigrationnon-intentionally added substancesultra-high-pressure liquid chromatography coupled with quadrupole time-of-flight mass spectrometry

Identifiers

PMID40646923
PMCPMC12248462

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.