ArticleAnimals : an open access journal from MDPI2025
Integrated mRNA and miRNA Analysis Reveals Layer-Specific Mechanisms of Antler Yield Variation in Sika Deer.
Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Review
- Article
- Genome-Wide Identification of Candidate Genes Associated with Antler Weight in Tahe Red Deer.Animals : an open access journal from MDPI · 2026Article
- Regulatory mechanisms of deer antler extracellular vesicles in multilevel tissue repair: a state-of-the-art review.Frontiers in pharmacology · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Antlers exhibit exceptionally rapid growth, representing a rare biological phenomenon among mammals. In addition to their scientific significance, antlers are widely used in traditional medicine, and their yield directly impacts the economic efficiency of the deer farming industry. However, antler yield varies substantially among individuals, and the molecular mechanisms underlying this variation remain poorly understood. This study aimed to elucidate the transcriptomic and post-transcriptional mechanisms underlying antler yield variation by comparing gene and miRNA expression profiles across four distinct antler tissue layers-dermis (D), reserve mesenchyme (RM), pre-cartilage (PC), and cartilage (C)-in sika deer with different yields. RNA-seq and miRNA-seq were performed, followed by differential expression, GO and KEGG pathway enrichment, and miRNA-mRNA co-expression network analyses. Our results reveal layer-specific expression patterns and key regulatory genes and miRNAs associated with proliferation, chondrogenesis, angiogenesis, and mineralization. In particular, genes such as
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Registered trials
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