Evidence map›Paper›PMID 40646740›Full record

ArticleAnimals : an open access journal from MDPI2025

Influence of Paratuberculosis Vaccination on the Local Immune Response in Experimentally Infected Calves: An Immunohistochemical Analysis.

David Zapico, José Espinosa, María Muñoz, Luis Ernesto Reyes, Julio Benavides, Juan Francisco García Marín, Miguel Fernández

Abstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David ZapicoDepartamento de Sanidad Animal, Facultad de Veterinaria, Universidad de León, C/ Profesor Pedro Cármenes s/n, E-24071 León, Spain.
José EspinosaDepartamento de Sanidad Animal, Facultad de Veterinaria, Universidad de León, C/ Profesor Pedro Cármenes s/n, E-24071 León, Spain.ORCID 0000-0002-9036-1402
María MuñozDepartamento de Sanidad Animal, Facultad de Veterinaria, Universidad de León, C/ Profesor Pedro Cármenes s/n, E-24071 León, Spain.
Luis Ernesto ReyesDepartamento de Sanidad Animal, Facultad de Veterinaria, Universidad de León, C/ Profesor Pedro Cármenes s/n, E-24071 León, Spain.
Julio BenavidesDepartamento de Sanidad Animal, Instituto de Ganadería de Montaña (CSIC-ULE), E-24346 Grulleros, Spain.
Juan Francisco García MarínDepartamento de Sanidad Animal, Facultad de Veterinaria, Universidad de León, C/ Profesor Pedro Cármenes s/n, E-24071 León, Spain.
Miguel FernándezDepartamento de Sanidad Animal, Facultad de Veterinaria, Universidad de León, C/ Profesor Pedro Cármenes s/n, E-24071 León, Spain.ORCID 0000-0002-4690-7770

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccination remains the most cost-effective way to control clinical paratuberculosis in dairy herds, but its effect on the immune response at the intestine have been poorly characterized. The aim of this study was to evaluate the expression of toll-like receptor (TLR)-1, TLR2, TLR4, TLR9, interferon (IFN)-γ, inducible nitric oxide synthase (iNOS) and cluster of differentiation (CD)-204 in calves vaccinated with Silirum

Indexed as

cattlegranulomaIFN-γlesionM1M2macrophageparatuberculosisTLRvaccination

Identifiers

PMID40646740
PMCPMC12248800

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.